Results 71 to 80 of about 680,317 (306)

Multiple sclerosis [PDF]

Journal of Clinical Investigation, 2012
Multiple sclerosis (MS) is a multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual. While the formation and persistence of meningeal lymphoid follicles suggest persistence of antigens to drive the continuing inflammatory and humoral response, the ...
Alyssa, Nylander, David A, Hafler
openaire   +2 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Mechanochemical ablation (MOCA) for superficial venous insufficiency: a protocol for a systematic review with meta-analysis [PDF]

Jornal Vascular Brasileiro
Varicose veins are a common disease worldwide, mainly affecting adults, and are estimated to be the 7th most common reason for physician referral in the USA. There is no ideal technique for treatment of varicose veins.
Simone Pedroso Jardim, Vinicius Farina Sartori, Iana Kátia Araújo Gonçalves, Carolina Dutra Queiroz Flumignan, Jorge Eduardo de Amorim, Ronald Luiz Gomes Flumignan, Luis Carlos Uta Nakano   +6 more
doaj   +2 more sources

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Treating Systematic Errors in Multiple Sclerosis Data [PDF]

, 2005
Multiple sclerosis (MS) is characterized by high variability between patients and, more importantly here, within an individual over time. This makes categorization and prognosis difficult.
Kappos, L., Polman, C., Ebers, G. C., Neiß, A., Vukusic, S., Heigenhauser, L., Confavreux, C., Daumer, Martin, Lederer, C., Ebers, C. G., Heigenhauser, Ludwig, Kappos, Ludwig   +11 more
core   +1 more source

Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis [PDF]

, 2006
Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator ...
Prinster, Anna
core   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Functional clinical outcomes in multiple sclerosis: Current status and future prospects [PDF]

, 2015
For decades, the Expanded Disability Status Scale (EDSS) has been the principal measure of disability in clinical trials in patients with multiple sclerosis (MS) and in clinical practice.
Deleu, Dirk T., Dahdaleh, Maurice P., Alroughani, Raed, Inshasi, Jihad Said, Yamout, Bassem I., Bohlega, Saeed A., Sahraian, Mohammed A., AlTahan, Abdulrahman M., Rieckmann, Peter, Al-Jumah, Mohammed A., Alsharoqi, Isa Ahmed, Deleu, Dirk, Aljumah, Mohammed, Daif, Abdulkader Kader M., Karabudak, Rana, Alroughani, Raed A., Sahraian, Mohammad Ali, Inshasi, Jihad S., Dahdaleh, Maurice, Alsharoqi, I. Ahmed, Amous, Amer, Daif, Abdulkader   +21 more
core   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Migration and infectious disease in the etiology of multiple sclerosis: A case-control study

, 1989
Epidemiological study on multiple sclerosis risk of migration from South to North ...
Altobelli A., Italian Multiple Sclerosis Study Group, GRANIERI, Enrico Gavino Giuseppe   +2 more
core