Results 41 to 50 of about 922,760 (302)
Increased circulating levels of vitamin D binding protein in MS patients [PDF]
, 2015 Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and ...
Cortese, Antonio +9 more
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mesial Temporal Lobe Epilepsy as a Common but Elusive Case: A Case Report
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah SurabayaEpilepsy is a common neuronal disorder that could include partial or generalized seizures due to abnormal brain electrical activity. A 32-year-old female patient was presented to the emergency room with a chief complaint of seizure.
Darren Junior +4 more
doaj +1 more source
Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022 The article presents the results of studies of variants of the development of sclerotic changes in the liver tissue, intrahepatic and extrahepatic ducts, as well as the walls of the gallbladder associated with various chronic diseases of the biliary ...
M.G. Fedorova +2 more
doaj +1 more source
Chronic foot ulcers – Rule out cutaneous tuberculosis!
Indian Journal of Paediatric Dermatology, 2021 Cutaneous tuberculosis is a form of extrapulmonary tuberculosis and is seen in a small but significant subset of patients seeking dermatology outpatient services. Children constitute a significant proportion of overall cases of cutaneous tuberculosis. We
Sunita Arora +2 more
doaj +1 more source
Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]
, 2006 It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Melorheostosis: Two atypical cases
Indian Journal of Radiology and Imaging, 2014 Melorheostosis is an uncommon mesenchymal dysplasia that rarely affects the axial skeleton.We describe two atypical cases of melorheostosis with classical imaging findings - the first one involving the cervico-dorsal spine with encroachment of left ...
Binit Sureka +5 more
doaj +1 more source
No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]
, 2006 Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Compston, A +7 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source