Results 171 to 180 of about 13,466 (213)

Intestinal Sclerostin Deficiency Links Gut Dysbiosis to Altered Serotonin Homeostasis in Axial Spondyloarthritis. [PDF]

Inflammation
Mauro D, Bergot AS, Guggino G, Salzillo A, Forte G, Ciancio A, Rizzo A, Raimondo S, Lentini L, Gandolfo S, Kim SP, Wong C, De Marino B, Milling S, Alessandro R, Panarese I, Riddle RC, Zaiss MM, McGonagle D, Thomas R, Ciccia F.   +20 more
europepmc   +1 more source

Dental and periodontal phenotype in sclerostin knockout mice [PDF]

International Journal of Oral Science, 2014
Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Reinhard Gruber, Ulrike Kuchler, Dieter Bosshardt   +2 more
exaly   +3 more sources

Sclerostin levels during growth in children

Osteoporosis International, 2011
Serum sclerostin levels are associated with cortical porosity, suggesting that changes in sclerostin production during growth may play a role in defining cortical structure.Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt ...
Sundeep Khosla
exaly   +2 more sources

Drug discovery of sclerostin inhibitors

Acta Pharmaceutica Sinica B, 2022
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases.
Huan Xiao, Ge Zhang, Meiheng Sun
exaly   +4 more sources

Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels

Journal of Bone and Mineral Research, 2013
We examined the effects that ovariectomy had on sclerostin mRNA and protein levels in the bones of 8-week-old mice that were either sham-operated (SHAM) or ovariectomized (OVX) and then euthanized 3 or 6 weeks later.
Elena Torreggiani, Faryal Mírzá, Marina Stolina   +2 more
exaly   +2 more sources

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Sclerostin deficiency in humans

Bone, 2017
Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a better understanding of the role of ...
Lierop, A.H. van, Appelman-Dijkstra, N.M., Papapoulos, S.E.   +2 more
openaire   +3 more sources

Hormonal and systemic regulation of sclerostin [PDF]

Bone, 2017
The Wnt/β-catenin signaling pathway plays an essential role in osteoblast biology. Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by osteocytes. Current evidence indicates that sclerostin likely functions as a local/paracrine regulator of bone metabolism rather than as an endocrine hormone.
Sundeep Khosla
exaly   +3 more sources

Sclerostin Enhances Adipocyte Differentiation in 3T3‐L1 Cells [PDF]

Journal of Cellular Biochemistry, 2016
Sclerostin, a secreted protein encoded by the Sost gene, is produced by osteocytes and is inhibited by osteoblast differentiation and bone formation. Recently, a functional association between bone and fat tissue has been suggested, and a correlation ...
Masato Tamura
exaly   +2 more sources

Sclerostin and skeletal health

Reviews in Endocrine and Metabolic Disorders, 2015
Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5 and 6 on the cell membrane of osteoblasts, it inhibits canonical Wnt/β-catenin signaling and reduces osteoblastic
Maryam, Sharifi, Lisa, Ereifej, E Michael, Lewiecki   +2 more
openaire   +2 more sources

Sclerostin

Current Opinion in Endocrinology, Diabetes & Obesity, 2014
Discovery of the Wnt signaling pathway and understanding the central role of osteocyte in skeletal homeostasis have been the major advances in skeletal biology over the past decade. Sclerostin, secreted mainly (but not exclusively) by osteocytes, has emerged as a key player in skeletal homeostasis.
Mahalakshmi, Honasoge, Ajay D, Rao, Sudhaker D, Rao   +2 more
openaire   +2 more sources