Results 171 to 180 of about 13,851 (214)
Dental and periodontal phenotype in sclerostin knockout mice [PDF]
International Journal of Oral Science, 2014 Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Reinhard Gruber +2 more
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Drug discovery of sclerostin inhibitors
Acta Pharmaceutica Sinica B, 2022 Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases.
Huan Xiao, Ge Zhang, Meiheng Sun
exaly +4 more sources
Sclerostin levels during growth in children
Osteoporosis International, 2011 Serum sclerostin levels are associated with cortical porosity, suggesting that changes in sclerostin production during growth may play a role in defining cortical structure.Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt ...
Sundeep Khosla, L Joseph Melton, S Amin
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Sclerostin deficiency in humans
Bone, 2017Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a better understanding of the role of ...
Lierop, A.H. van +2 more
openaire +3 more sources
Sclerostin and skeletal health
Reviews in Endocrine and Metabolic Disorders, 2015Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5 and 6 on the cell membrane of osteoblasts, it inhibits canonical Wnt/β-catenin signaling and reduces osteoblastic
Maryam, Sharifi +2 more
openaire +2 more sources
Current Opinion in Endocrinology, Diabetes & Obesity, 2014
Discovery of the Wnt signaling pathway and understanding the central role of osteocyte in skeletal homeostasis have been the major advances in skeletal biology over the past decade. Sclerostin, secreted mainly (but not exclusively) by osteocytes, has emerged as a key player in skeletal homeostasis.
Mahalakshmi, Honasoge +2 more
openaire +2 more sources
Discovery of the Wnt signaling pathway and understanding the central role of osteocyte in skeletal homeostasis have been the major advances in skeletal biology over the past decade. Sclerostin, secreted mainly (but not exclusively) by osteocytes, has emerged as a key player in skeletal homeostasis.
Mahalakshmi, Honasoge +2 more
openaire +2 more sources
Role of Sclerostin in Cardiovascular Disease
Arteriosclerosis, Thrombosis, and Vascular Biology, 2022Sclerostin is most recognized for its role in controlling bone formation but is also expressed in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on sclerostin’s role in cardiovascular disease. Rodent studies have found sclerostin to be expressed at sites of arterial calcification.
Jonathan Golledge +1 more
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Sclerostin: from bench to bedside
Journal of Bone and Mineral Metabolism, 2020Skeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. The SOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible
Sakae Tanaka, Toshio Matsumoto
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Hormonal and systemic regulation of sclerostin [PDF]
Bone, 2017 The Wnt/β-catenin signaling pathway plays an essential role in osteoblast biology. Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by osteocytes. Current evidence indicates that sclerostin likely functions as a local/paracrine regulator of bone metabolism rather than as an endocrine hormone.
Sundeep Khosla
exaly +3 more sources