Results 181 to 190 of about 13,466 (213)
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Sclerostin: from bench to bedside
Journal of Bone and Mineral Metabolism, 2020Skeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. The SOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible
Sakae Tanaka, Toshio Matsumoto
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The Role of Sclerostin in Bone and Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2020 Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney ...
Anja Verhulst +2 more
exaly +4 more sources
Anti-sclerostin – is there an indication?
Injury, 2016Several decades ago, a clinical condition that included severe bone overgrowth was described in a few patients in South Africa. The autosomal-recessive disease that later was named sclerosteosis was found to be caused by a mutation in the SOTS gene causing a lack of the protein sclerostin. This protein is produced by osteocytes and exerts its effect as
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Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments [PDF]
Bone, 2018 Sclerostin is a 190 amino acid protein secreted primarily by osteocytes. It was initially identified due to mutations in the SOST gene associated with high bone mass phenotypes. Much recent work has sought to determine the importance of sclerostin across an array of conditions which affect the human skeleton. However, accurate measurement of sclerostin
Natasha M Appelman-Dijkstra +2 more
exaly +3 more sources
Sclerostin in Obstructive Sleep Apnea
2015Sclerostin, a glycoprotein involved in vascular calcification, could play a role in cardiovascular disorders. Obstructive sleep apnea (OSA) is frequently associated with cardiovascular comorbidities. Thus, in this study we set out to assess the level of sclerostin in patients with OSA.
M, Kosacka, I, Porębska, A, Brzecka
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Current Osteoporosis Reports, 2015
Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Interactions between Sclerostin and Glycosaminoglycans
Glycoconjugate Journal, 2019Sclerostin (SOST) is a glycoprotein having many important functions in the regulation of bone formation as a key negative regulator of Wnt signaling in bone. Surface plasmon resonance (SPR), which allows for a direct quantitative analysis of the label-free molecular interactions in real-time, has been widely used for the biophysical characterization of
Fuming Zhang +3 more
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Sclerostin and DKK1 in Primary Hyperparathyroidism
Calcified Tissue International, 2013Bone formation is influenced by the Wnt pathway through effects on osteoblast functionality, and these actions are opposed by two antagonists: sclerostin and Dickkopf-1 (DKK1). Decreased levels of serum sclerostin were found after treatment with the PTH analogue teriparatide and in patients with primary hyperparathyroidism (PHPT), while treatment with ...
VIAPIANA, Ombretta +6 more
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The association of sclerostin serum levels with sclerostin expression in bone
Endocrine Abstracts, 2015Nathalie Bravenboer +9 more
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