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Anti-sclerostin – is there an indication?
Injury, 2016Several decades ago, a clinical condition that included severe bone overgrowth was described in a few patients in South Africa. The autosomal-recessive disease that later was named sclerosteosis was found to be caused by a mutation in the SOTS gene causing a lack of the protein sclerostin. This protein is produced by osteocytes and exerts its effect as
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Sclerostin in Obstructive Sleep Apnea
2015Sclerostin, a glycoprotein involved in vascular calcification, could play a role in cardiovascular disorders. Obstructive sleep apnea (OSA) is frequently associated with cardiovascular comorbidities. Thus, in this study we set out to assess the level of sclerostin in patients with OSA.
M, Kosacka, I, Porębska, A, Brzecka
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Current Osteoporosis Reports, 2015
Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Interactions between Sclerostin and Glycosaminoglycans
Glycoconjugate Journal, 2019Sclerostin (SOST) is a glycoprotein having many important functions in the regulation of bone formation as a key negative regulator of Wnt signaling in bone. Surface plasmon resonance (SPR), which allows for a direct quantitative analysis of the label-free molecular interactions in real-time, has been widely used for the biophysical characterization of
Fuming Zhang +3 more
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Sclerostin and DKK1 in Primary Hyperparathyroidism
Calcified Tissue International, 2013Bone formation is influenced by the Wnt pathway through effects on osteoblast functionality, and these actions are opposed by two antagonists: sclerostin and Dickkopf-1 (DKK1). Decreased levels of serum sclerostin were found after treatment with the PTH analogue teriparatide and in patients with primary hyperparathyroidism (PHPT), while treatment with ...
VIAPIANA, Ombretta +6 more
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The association of sclerostin serum levels with sclerostin expression in bone
Endocrine Abstracts, 2015Nathalie Bravenboer +9 more
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Relation of age, gender, and bone mass to circulating sclerostin levels in women and men
Journal of Bone and Mineral Research, 2011Sundeep Khosla +2 more
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