Results 231 to 240 of about 20,344 (273)
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Sclerostin: from bench to bedside
Journal of Bone and Mineral Metabolism, 2020Skeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. The SOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible
Sakae Tanaka, Toshio Matsumoto
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Sclerostin and skeletal health
Reviews in Endocrine and Metabolic Disorders, 2015Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5 and 6 on the cell membrane of osteoblasts, it inhibits canonical Wnt/β-catenin signaling and reduces osteoblastic
Maryam, Sharifi +2 more
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Role of Sclerostin in Cardiovascular Disease
Arteriosclerosis, Thrombosis, and Vascular Biology, 2022Sclerostin is most recognized for its role in controlling bone formation but is also expressed in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on sclerostin’s role in cardiovascular disease. Rodent studies have found sclerostin to be expressed at sites of arterial calcification.
Jonathan Golledge +1 more
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Sclerostin Deficiency Promotes Reparative Dentinogenesis
Journal of Dental Research, 2017In humans, the SOST gene encodes sclerostin, an inhibitor of bone growth and remodeling, which also negatively regulates the bone repair process. Sclerostin has also been implicated in tooth formation, but its potential role in pulp healing remains unknown.
Collignon, A.-M. +10 more
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Interactions between Sclerostin and Glycosaminoglycans
Glycoconjugate Journal, 2019Sclerostin (SOST) is a glycoprotein having many important functions in the regulation of bone formation as a key negative regulator of Wnt signaling in bone. Surface plasmon resonance (SPR), which allows for a direct quantitative analysis of the label-free molecular interactions in real-time, has been widely used for the biophysical characterization of
Fuming Zhang +3 more
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Sclerostin in Obstructive Sleep Apnea
2015Sclerostin, a glycoprotein involved in vascular calcification, could play a role in cardiovascular disorders. Obstructive sleep apnea (OSA) is frequently associated with cardiovascular comorbidities. Thus, in this study we set out to assess the level of sclerostin in patients with OSA.
M, Kosacka, I, Porębska, A, Brzecka
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Current Osteoporosis Reports, 2015
Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Declining kidney function is associated with sequential systemic changes in mineral homeostasis leading to pathologic alterations in the cardiovascular system and the skeleton. One of the earliest changes in response to renal injury is the increased osteocyte production of secreted factors including the anti-anabolic protein, sclerostin.
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Sclerostin and DKK1 in Primary Hyperparathyroidism
Calcified Tissue International, 2013Bone formation is influenced by the Wnt pathway through effects on osteoblast functionality, and these actions are opposed by two antagonists: sclerostin and Dickkopf-1 (DKK1). Decreased levels of serum sclerostin were found after treatment with the PTH analogue teriparatide and in patients with primary hyperparathyroidism (PHPT), while treatment with ...
VIAPIANA, Ombretta +6 more
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Current Molecular Biology Reports, 2017
Since its discovery 15 years ago, inhibition of sclerostin has come to be identified as a potent anabolic agent. The sclerostin neutralizing antibody, romosozumab, is a promising treatment for postmenopausal osteoporosis. Animal studies also show a role of sclerostin in regulating hematopoietic cells and, more recently, adipocytes.
Keertik Fulzele, Paola Divieti Pajevic
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Since its discovery 15 years ago, inhibition of sclerostin has come to be identified as a potent anabolic agent. The sclerostin neutralizing antibody, romosozumab, is a promising treatment for postmenopausal osteoporosis. Animal studies also show a role of sclerostin in regulating hematopoietic cells and, more recently, adipocytes.
Keertik Fulzele, Paola Divieti Pajevic
openaire +1 more source