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Clinical calcium, 2011
Sclerostin is a secreted protein from osteocytes that inhibits Wnt signaling. Wnt signalling plays important roles in osteoblastic differentiation hence bone formation. Therefore, inhibition of sclerostin promotes bone formation. A monoclonal antibody has been generated against sclerostin, which has been shown to stimulate bone formation and increase ...
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Sclerostin is a secreted protein from osteocytes that inhibits Wnt signaling. Wnt signalling plays important roles in osteoblastic differentiation hence bone formation. Therefore, inhibition of sclerostin promotes bone formation. A monoclonal antibody has been generated against sclerostin, which has been shown to stimulate bone formation and increase ...
openaire +1 more source
Clinical utility of anti-sclerostin antibodies
Bone, 2017Based on a platform of strong preclinical data, several studies in humans have demonstrated that inhibiting sclerostin with specific antibodies results in a brisk albeit transient anabolic response in the skeleton without an accompanying increase in bone resorption.
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Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases
Endocrine Reviews, 2012Hua Zhu Ke
exaly
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Nature Communications, 2016Marina Stolina
exaly