Results 261 to 270 of about 25,148 (309)

Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease

Promruk W, Jayash S, Chutoe C, Ke HZ, Liu X, von Kriegsheim A, Cawthorn W, Staines K, Stephen L, Farquharson C.   +9 more
europepmc   +1 more source

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Role of Wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders

Osteoporosis International, 2022
Francesca Marini, Francesca Giusti, Gaia Palmini   +2 more
exaly   +2 more sources

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial

Lancet, The, 2017
Cesar Libanati, Jacques P Brown, Klaus Engelke   +2 more
exaly   +2 more sources

Baicalin Nanocomplexes with an In Situ-Forming Biomimetic Gel Implant for Repair of Calvarial Bone Defects via Localized Sclerostin Inhibition.

ACS Applied Materials and Interfaces, 2023
In situ-forming hydrogels are highly effective in covering complex and irregular tissue defects. Herein, a biomimetic gel implant (CS-GEL) consisting of methacrylated chondroitin sulfate and gelatin is obtained via visible light irradiation, which ...
Chenrui Li, Junru Wang, Yining Niu, Haonan Zhang, Hongling Ouyang, Guangwei Zhang, Yao Fu   +6 more
semanticscholar   +1 more source

Dental and periodontal phenotype in sclerostin knockout mice [PDF]

International Journal of Oral Science, 2014
Ulrike Kuchler, Uwe Yacine Schwarze, Toni Dobsak   +2 more
exaly   +2 more sources

Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin-/- mice through increasing sclerostin and RANKL/OPG.

Bone, 2022
BACKGROUND Numerous studies have demonstrated that iron overload is a risk factor of osteoporosis. However, there has been no systematic and in-depth studies on the effect of iron overload on osteocytes and its role in iron overload-induced bone loss ...
Jiawei Ma, Aifei Wang, Hui Zhang, Baoshan Liu, Yu Geng, Youjia Xu, Guilai Zuo, P. Jia   +7 more
semanticscholar   +1 more source

Sclerostin

Current Opinion in Endocrinology, Diabetes & Obesity, 2014
Discovery of the Wnt signaling pathway and understanding the central role of osteocyte in skeletal homeostasis have been the major advances in skeletal biology over the past decade. Sclerostin, secreted mainly (but not exclusively) by osteocytes, has emerged as a key player in skeletal homeostasis.
Mahalakshmi, Honasoge, Ajay D, Rao, Sudhaker D, Rao   +2 more
openaire   +2 more sources

Sclerostin deficiency in humans

Bone, 2017
Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a better understanding of the role of ...
Lierop, A.H. van, Appelman-Dijkstra, N.M., Papapoulos, S.E.   +2 more
openaire   +3 more sources

Sclerostin: from bench to bedside

Journal of Bone and Mineral Metabolism, 2020
Skeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. The SOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible
Sakae Tanaka, Toshio Matsumoto
openaire   +2 more sources

Sclerostin and skeletal health

Reviews in Endocrine and Metabolic Disorders, 2015
Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5 and 6 on the cell membrane of osteoblasts, it inhibits canonical Wnt/β-catenin signaling and reduces osteoblastic
Maryam, Sharifi, Lisa, Ereifej, E Michael, Lewiecki   +2 more
openaire   +2 more sources