Results 281 to 290 of about 25,148 (309)

[Anti-sclerostin antibodies].

Clinical calcium, 2011
Sclerostin is a secreted protein from osteocytes that inhibits Wnt signaling. Wnt signalling plays important roles in osteoblastic differentiation hence bone formation. Therefore, inhibition of sclerostin promotes bone formation. A monoclonal antibody has been generated against sclerostin, which has been shown to stimulate bone formation and increase ...
openaire   +1 more source

Clinical utility of anti-sclerostin antibodies

Bone, 2017
Based on a platform of strong preclinical data, several studies in humans have demonstrated that inhibiting sclerostin with specific antibodies results in a brisk albeit transient anabolic response in the skeleton without an accompanying increase in bone resorption.
openaire   +4 more sources

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression

Nature Metabolism
T. Shi, Siyu Shen, Yong Shi, Qianjin Wang, Guanqun Zhang, Jiaquan Lin, Jiang Chen, Feng Bai, Lei Zhang, Yang-Gao Wang, Wang Gong, Xiaoyan Shao, Guiquan Chen, Wenjin Yan, Xiang Chen, Yuze Ma, Liming Zheng, Jianghui Qin, Ke Lu, Na Liu, Yun Xu, Y. Shi, Qing Jiang, Baosheng Guo   +23 more
semanticscholar   +1 more source

Sclerostin and body fat

Medicina Clínica (English Edition), 2015
Geraldine, Quintero-Platt, Onán, Pérez-Hernández, María José, de la Vega Prieto, Emilio, González-Reimers   +3 more
openaire   +2 more sources

SOST/Sclerostin

2008
Rutger L. van Bezooijen, Socrates E. Papapoulos, Neveen A.T. Hamdy, Clemens W.G.M. Löwik   +3 more
openaire   +1 more source

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Journal of Bone and Mineral Research, 2008
Marina Stolina, Hua Zhu Ke
exaly  

Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases

Endocrine Reviews, 2012
Hua Zhu Ke
exaly  

Relation of age, gender, and bone mass to circulating sclerostin levels in women and men

Journal of Bone and Mineral Research, 2011
Sundeep Khosla
exaly  

The association of sclerostin serum levels with sclerostin expression in bone

Endocrine Abstracts, 2015
Nathalie Bravenboer, Ruben Visser, Dirk Jan Mons, Angela Oostlander, Eveline Sohl, Essen Hub van, Jongh Renate de, Paul Lips, Annemieke Heijboer, Heijer Martin den   +9 more
openaire   +1 more source

Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Suppressing Inflammatory Responses

Metabolism, 2023
Luyao Wang, Ning Zhang, Jin Liu, Xin Yang, Yuanyuan Yu, Dijie Li, Hewen Jiang, Meiheng Sun, Nanxi LI, Daqing Ma, Yu Huang, Aiping Lu, Baoting Zhang, Ge Zhang   +13 more
openaire   +1 more source