Results 91 to 100 of about 496,844 (305)

Adaptive learning program for developing employability skills [PDF]

, 2018
The paper aims to demonstrate the benefits of adaptive learning technologies as a viable alternative to time consuming tutor led individual support. It proposes to reveal how adaptive learning interventions can be effective in enriching student learning ...
Jackson, Timothy P., Oliver, Stanley
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Telehealth in trauma: A scoping review

Journal of Telemedicine and Telecare, 2020
Background The purpose of this scoping review was to ascertain how ‘telehealth’ is utilised within health care, from pre hospital to admission, discharge and post discharge, with patients who have suffered major trauma. Methods A scoping review of the literature published in English since 1980 was conducted using MEDLINE, Ovid EMBASE, PsychINFO, CINAHL,
Elizabeth Wake, Heidi Atkins, Ashley Willock, Angela Hawkes, Jessica Dawber, Kelly A Weir   +5 more
openaire   +4 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Considerations for conducting a scoping review in pharmacy education

Exploratory Research in Clinical and Social Pharmacy
Interrogating the literature is among the first steps a researcher undertakes when actuating a research project or also when any scholar might seek to know what has been done in an area, best practices for conducting a certain activity, or simply to seek
Cherie Lucas, Shane P. Desselle
doaj   +1 more source

Community Health Champions in Lincolnshire Review and Scoping Exercise Report [PDF]

, 2013
The Lincolnshire 2012 Joint Health and Well-being Strategy identified the need to ‘develop a Community Health Champion programme for Lincolnshire building on current good practice that will enable people to volunteer to offer help and support to other ...
White, J, Woodward, J
core  

International perspectives on social media guidance for nurses: a content analysis [PDF]

, 2015
Aim: This article reports the results of an analysis of the content of national and international professional guidance on social media for the nursing profession.
Ryan, Gemma
core   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source