Results 111 to 120 of about 496,844 (305)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A scoping review of the psychosocial aspects of infertility in African countries

Reproductive Health
Infertility refers to the inability to conceive after 12 months of regular, unprotected sexual intercourse. Psychosocial aspects of infertility research are predominant in developed countries.
R. Roomaney, M. Salie, D. Jenkins, C. Eder, M. J. Mutumba-Nakalembe, C. Volks, N. Holland, K. Silingile   +7 more
doaj   +1 more source

Securing the Livelihoods and Nutritional Needs of Fish-Dependent Communities [PDF]

, 2013
Starting in June 2012, the Rockefeller Foundation began investigating the pressing problem of the declining health of the oceans due to climate change, overfishing, pollution and habitat destruction, and the effects of this decline on poor and vulnerable
Amanda Goldberger, Laura Herman, Leigh Fiske   +2 more
core  

Do people with intellectual disabilities understand their prescription medication? A scoping review [PDF]

, 2019
© 2019 The Authors. Journal of Applied Research in Intellectual Disabilities Published by John Wiley & Sons Ltd.Background: People with intellectual disabilities are more likely to experience poor health than the general population and are frequently ...
Adams D., Adams D., Dunn K., General Medical Council, Glover G., Mencap, NHS Confederation, NHS Digital, NHS England, NHS England, NHS England, NICE, NICE, Royal College of Nursing, Straetmans J. M., The Disability Partnership   +15 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Suicidal ambivalence: A scoping review

Suicide and Life-Threatening Behavior
AbstractBackgroundSuicidal ambivalence is considered a characteristic condition of suicidal individuals. At the same time, there is a lack of a uniform definition, conception and assessment of suicidal ambivalence. On this background, the current scoping review aims to explore the extent, range, and nature of research activity on suicidal ambivalence ...
Tobias Teismann, Annika Maria Siebert, Thomas Forkmann   +2 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Telehealth in sarcoidosis: a scoping review

BMC Pulmonary Medicine
Introduction Sarcoidosis is an inflammatory disease that causes functional and physical limitations in patients, negatively impacting their quality of life.
Lida Fadaizadeh, Farnia Velayati, Hassan Shojaee-Mend   +2 more
doaj   +1 more source

Academic Socialization and Its Effects on Academic Success [PDF]

, 2020
Academic Socialization and Its Effects on Academic Success David Lim, Dept. of Psychology and Maria J. Cisneros-Elias, Dept. of Psychology Graduate Student, with Dr. Chelsea D. Williams, Dept.
Cisneros-Elias, Maria, Lim, David
core   +1 more source