Results 41 to 50 of about 42,633 (246)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Policy and strategies addressing prevention and control of antimicrobial resistance in Brazil: A scoping review protocol.

PLoS ONE, 2022
IntroductionAntimicrobial resistance (AMR) is considered one of the biggest health challenges of the 21st century. It has both social and economic consequences; therefore, timely review of public health policies that have been designed to manage AMR is ...
Joslaine de Oliveira Nunes, Raissa Allan Santos Domingues, Roberto Mauro Pinto Coelho Barcellos, Bárbara Manuella Cardoso Sodré Alves, Isis Polianna Silva Ferreira de Carvalho, Noemia Urruth Leão Tavares   +5 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Growth and differentiation factors and their orthodontic implications: A scoping review

MethodsX
Background: Growth and differentiation factors (GDFs) are a class of biological mediators that play an important role to stimulate and regulate the wound healing process. Some of the GDFs are known to play a role in orthodontics.
Crystal Runa Soans, M.S. Ravi, Monisha P Chelery, Sujata Shirodkar, Prachi Pundir, Shradha S. Parsekar   +5 more
doaj   +1 more source

Application of the capability approach to Indigenous People’s health and well-being: protocol for a mixed-methods scoping review

BMJ Open, 2022
Background Indigenous Peoples are subject to marginalisation, and experience systematic disadvantage in relation to health outcomes. Human development initiatives may help determine whether, and how, Indigenous Peoples are able to be agents of their own ...
Anna Chiumento, Catharina van der Boor, Carlos Iván Molina-Bulla, Ross G White   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Methodology for Assessing University Members’ Health and Well-Being and Their Influencing Factors: Protocol for a Rapid Scoping Review of Survey-Based Research

JMIR Research Protocols
BackgroundThis scoping review protocol addresses the imperative need for a comprehensive understanding of the health and well-being of university members, aligning with the global recognition of universities as pivotal in ...
Varga Zsuzsanna, László Balkányi, Anikó Gyulai, László Lippai, Andrea Mária Rucska†, Zsuzsanna Soósné Kiss, Péter Varsányi, József Vitrai, Boróka Gács   +8 more
doaj   +1 more source