Results 61 to 70 of about 187,831 (345)

Application of the capability approach to Indigenous People’s health and well-being: protocol for a mixed-methods scoping review

BMJ Open, 2022
Background Indigenous Peoples are subject to marginalisation, and experience systematic disadvantage in relation to health outcomes. Human development initiatives may help determine whether, and how, Indigenous Peoples are able to be agents of their own ...
Anna Chiumento, Catharina van der Boor, Carlos Iván Molina-Bulla, Ross G White   +3 more
doaj   +1 more source

Interventions by healthcare professionals to improve management of physical long-term conditions in adults who are homeless: a systematic review protocol [PDF]

, 2017
Introduction People experiencing homelessness are at increased risk of, and have poorer outcomes from, a range of physical long-term conditions (LTCs). It is increasingly recognised that interventions targeting people who are homeless should be tailored ...
Esiovwa, Regina, Gibson, Lauren, Hanlon, Peter, Lowrie, Richard, Mair, Frances S., Williamson, Andrea E., Yeoman, Lynsey   +6 more
core   +3 more sources

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Growth and differentiation factors and their orthodontic implications: A scoping review

MethodsX
Background: Growth and differentiation factors (GDFs) are a class of biological mediators that play an important role to stimulate and regulate the wound healing process. Some of the GDFs are known to play a role in orthodontics.
Crystal Runa Soans, M.S. Ravi, Monisha P Chelery, Sujata Shirodkar, Prachi Pundir, Shradha S. Parsekar   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Applications of implementation science frameworks, models and theories in disparities-focused cancer screening interventions: a scoping review protocol

BMJ Open, 2023
Background Implementation science (IS) frameworks, models and theories (FMTs) have gained popularity in guiding the implementation and evaluation of evidence-based interventions (EBIs) for cancer screening. However, there are significant research gaps in
Serena Xiong, Lisa Klesges, Michelle Doering, Rebekah J Pratt   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Methodology for Assessing University Members’ Health and Well-Being and Their Influencing Factors: Protocol for a Rapid Scoping Review of Survey-Based Research

JMIR Research Protocols
BackgroundThis scoping review protocol addresses the imperative need for a comprehensive understanding of the health and well-being of university members, aligning with the global recognition of universities as pivotal in ...
Varga Zsuzsanna, László Balkányi, Anikó Gyulai, László Lippai, Andrea Mária Rucska†, Zsuzsanna Soósné Kiss, Péter Varsányi, József Vitrai, Boróka Gács   +8 more
doaj   +1 more source