Results 51 to 60 of about 1,836,547 (316)

Scoring functions for drug-effect similarity [PDF]

open access: yesBriefings in Bioinformatics, 2020
Abstract Motivation The difficulty to find new drugs and bring them to the market has led to an increased interest to find new applications for known compounds. Biological samples from many disease contexts have been extensively profiled by transcriptomics, and, intuitively, this motivates to search ...
Stephan Struckmann   +5 more
openaire   +2 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

MULTICRITERIA DECISION MAKING BASED ON CUBIC SET

open access: yesJournal of New Theory, 2017
Abstaract−This paper solves multicriteria decision making problems based on cubic set. The whole cubic set information given by the decision maker has been presented in a matrix form along with the weights assigned to each criteria.
Tahir Mahmood   +3 more
doaj  

Solving fully neutrosophic linear programming problem with application to stock portfolio selection

open access: yesCroatian Operational Research Review, 2020
Neutrosophic set is considered as a generalized of crisp set, fuzzy set, and intuitionistic fuzzy set for representing the uncertainty, inconsistency, and incomplete knowledge about the real world problems.
Hamiden Abd El-Wahed Khalifa   +1 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Novel Parameterized Score Functions on Interval-Valued Intuitionistic Fuzzy Sets With Three Fuzziness Measure Indexes and Their Application

open access: yesIEEE Access, 2019
To explore the essential law of fuzziness of interval-valued intuitionistic fuzzy sets (IVIFSs), the entropy brought by interval values is studied.
Fangwei Zhang   +4 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

The characterisation of scoring functions [PDF]

open access: yesJournal of the Australian Mathematical Society, 2001
AbstractThe literature on subjective probabilities contains a number of functions that have been proposed as ‘scoring functions’. The principal requirement is that, with several events that may occur in the future and to which subjective ‘probabilities’ are assigned, the expected score given by these ‘probabilities’ will be extremised if the values ...
openaire   +2 more sources

Scoring functions in protein folding and design [PDF]

open access: yesProtein Science, 2000
AbstractWe present an analysis of the assumptions behind some of the most commonly used methods for evaluating the goodness of the fit between a sequence and a structure. Our studies on a lattice model show that methods based on statistical considerations are easy to use and can capture some of the features of protein‐like sequences and their ...
R. DIMA, J. R. BANAVAR, MARITAN, AMOS
openaire   +3 more sources

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