Results 181 to 190 of about 4,813,469 (351)

Efficacy of Item Response Theory in the Validation and Score Ranking of Dichotomous Response Mathematics Achievement Test

, 2020
Musa Adekunle Ayanwale, Joshua O. Adeleke   +1 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Relating drug response to epigenetic and genetic markers using a region-based kernel score test. [PDF]

BMC Proc, 2018
Yasmeen S, Burger P, Friedrichs S, Papiol S, Bickeböller H.   +4 more
europepmc   +1 more source

The fecal hemoglobin concentration, age and sex test score: Development and external validation of a simple prediction tool for colorectal cancer detection in symptomatic patients [PDF]

, 2017
Joaquín Cubiella, Jayne Digby, Lorena Rodríguez‐Alonso, Pablo Vega, María Salve, Marta Díaz-Ondina, Judith A Strachan, Craig Mowat, Paula McDonald, Francis A. Carey, Ian M Godber, Hakim Ben Younes, Francisco Rodríguez‐Moranta, Enrique Quintero, Victoria Álvarez-Sánchez, Fernando Fernández‐Bañares, Jaume Boadas, Rafel Campo, Luís Bujanda, Ana Garayoa, Ángel Ferrández, Virgı́nia Piñol, Daniel Rodríguez‐Alcalde, Jordi Guardiola, R. Steele, Callum G. Fraser, on behalf of the COLONPREDICT study investigators   +26 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A score test for genetic class-level association with nonlinear biomarker trajectories. [PDF]

Stat Med, 2017
Qian J, Nunez S, Kim S, Reilly MP, Foulkes AS.   +4 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Estimasi of True Score and Standard Error Measurement of Teacher Made in Mathematics Subject According to Classical Test Theory at the Junior High School Level

, 2021
Rasmuin Rasmuin, Desy Rahayu
openalex   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Kernel machine score test for pathway analysis in the presence of semi-competing risks. [PDF]

Stat Methods Med Res, 2018
Neykov M, Hejblum BP, Sinnott JA.
europepmc   +1 more source