Results 131 to 140 of about 1,186,164 (296)
A Scoring Rule-Based Mechanism for Aggregate Demand Prediction in the Smart Grid
, 2012 This paper presents a novel scoring rule-based strictly dominant incentive compatible mechanism that encourages agents to produce costly estimates of future events and report them truthfully to a centre.
Rose, Harry +2 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Simulated adjustment of the signed scoring rule root statistic
, 2015 We focus on adjustments of the signed scoring rule root statistic generalizing results for likelihood quantities. In particular, for a scalar parameter of interest, we investigate a bootstrap adjustment of the signed scoring rule root statistic.
L. Ventura +5 more
core
Theoretical Economics, 2020 Is it possible to guarantee that the mere exposure of a subject to a belief elicitation task will not affect the very same beliefs that we are trying to elicit? In this paper, we introduce mechanisms that make it simultaneously strictly dominant for the subject (a) not to acquire any information that could potentially lead to belief updating as a ...
openaire +4 more sources
A Multi-Source Feedback-Driven Framework for Generating WAF Test Cases
Future InternetWeb application firewalls (WAFs) are critical defenses against persistent threats to web applications, yet their security evaluation remains challenging.
Pengcheng Lu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Axiomatic Characterization of the Quadratic Scoring Rule
In the evaluation of experiments often the problem arises of how to compare the predictive success of competing probabilistic theories. The quadratic scoring rule can be used for this purpose. Originally, this rule was proposed as an incentive compatible
Reinhard Selten
core +1 more source