Results 111 to 120 of about 148,797 (204)

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers. [PDF]

J Neurobiol Physiol, 2022
Gurevitz M, Zhorov BS, Dong K.
europepmc   +1 more source

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na_V1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. [PDF]

Front Pharmacol, 2022
George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH.   +12 more
europepmc   +1 more source

New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1.

, 2002
Udgivelsesdato: 2002-Nov-8The scorpion toxin BeKm-1 is unique among a variety of known short scorpion toxins affecting potassium channels in its selective action on ether-a-go-go-related gene (ERG)-type channels.
Olesen, Søren-Peter, Bocharov, Eduard V, Maslennikov, Innokenty V, Nosyreva, Elena D, Arseniev, Alexander S, Lipkin, Aleksey V, Angelo, Kamilla, Pluzhnikov, Kirill A, Grishin, Eugene V, Korolkova, Yuliya V, Grinenko, Olga V   +10 more
core   +1 more source

Scorpion IX [PDF]

, 1970
Issue 9 announced that all articles would be anonymous, because of the situation discussed in Issue 8. Many of the articles address lack of communication between the administration and students.
The Scorpion Staff
core   +1 more source

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin. [PDF]

Nat Commun, 2021
Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomès R, Zheng N, Catterall WA.   +6 more
europepmc   +1 more source

Scorpion V [PDF]

, 1969
Issue 5 comments on restrictive dorm policies for women, mocks the PE major, and looks at the theory behind the modern educational system. There are also several articles about the military and war as well as a number of poems on various topics.
The Scorpion Staff
core   +1 more source

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. [PDF]

Curr Res Struct Biol, 2021
Sharma G, Braga CB, Chen KE, Jia X, Ramanujam V, Collins BM, Rittner R, Mobli M.   +7 more
europepmc   +1 more source

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K⁺ Channel K_V1.2 and Small- and Intermediate-Conductance Ca²⁺-Activated K⁺ Channels K_Ca2.2 and K_Ca3.1. [PDF]

Toxins (Basel), 2023
Naseem MU, Gurrola-Briones G, Romero-Imbachi MR, Borrego J, Carcamo-Noriega E, Beltrán-Vidal J, Zamudio FZ, Shakeel K, Possani LD, Panyi G.   +9 more
europepmc   +1 more source

Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs

, 2016
Nine different voltage-gated sodium channel isoforms are responsible for inducing and propagating action potentials in the mammalian nervous system. The Na(v)1.7 channel isoform plays an important role in conducting nociceptive signals.
Adams, David J., Durek, Thomas, Motin, Leonid   +2 more
core   +1 more source

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

, 2018
We report the chemical synthesis of scorpion toxin Cn2, a potent and highly selective activator of the human voltage-gated sodium channel NaV1.6. In an attempt to decouple channel activation from channel binding, we also synthesized the first analogue of
Jennifer R. Deuis, Deuis, Jennifer R., Thongyoo, Panumart, Durek, Thomas, David J. Craik, Thomas Durek, Mathilde R. Israel, Israel, Mathilde R., Craik, David J., Vetter, Irina, Panumart Thongyoo, Irina Vetter   +11 more
core   +1 more source