Results 111 to 120 of about 10,029 (219)

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

Biomolecules
Scorpion neurotoxins are small peptides that target ion channels and offer opportunities for novel therapeutic discovery. This study analyzed the functional effects of the venom and toxins from the Costa Rican endemic scorpion, Tityus championi ...
Galit Akerman-Sánchez, Steve Peigneur, Kathleen Carleer, Natalia Ortiz, Felipe Navia, Leonardo Fierro, Santiago Castaño, Cecilia Díaz, Jan Tytgat, Oscar Brenes   +9 more
doaj   +1 more source

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na_V1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. [PDF]

Front Pharmacol, 2022
George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH.   +12 more
europepmc   +1 more source

Bioinformatics analysis of analgesic-antitumor like peptide from Iranian scorpion Mesobuthus eupeus [PDF]

, 2016
زمینه و هدف: در سال های اخیر مطالعات متعددی بر روی سموم حیوانات و حشرات برای یافتن مولکول هایی با خواص دارویی انجام شده است. سموم عقرب دارای مولکول های کوچکی با خواص زیستی و دارویی مختلف می باشند.
Ayat, Hoda., Dehghan, Zeinab., Mohammad Ahadi, Ali.   +2 more
core   +1 more source

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K⁺ Channel K_V1.2 and Small- and Intermediate-Conductance Ca²⁺-Activated K⁺ Channels K_Ca2.2 and K_Ca3.1. [PDF]

Toxins (Basel), 2023
Naseem MU, Gurrola-Briones G, Romero-Imbachi MR, Borrego J, Carcamo-Noriega E, Beltrán-Vidal J, Zamudio FZ, Shakeel K, Possani LD, Panyi G.   +9 more
europepmc   +1 more source

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. [PDF]

Curr Res Struct Biol, 2021
Sharma G, Braga CB, Chen KE, Jia X, Ramanujam V, Collins BM, Rittner R, Mobli M.   +7 more
europepmc   +1 more source

Reviewing science and technology in the context of the Biological Weapons Convention [PDF]

, 2010
There is evidence of the emergence of a consensus amongst a number of States Parties to the BWC and NGOs on the principle of changing the process of S&T review as part of the wider quinquennial review process of the BWC. However, there is little evidence
McLeish, Caitriona, Revill, James
core  

Expression of a tick toxin for the development of a canine vaccine [PDF]

, 2001
University of Technology, Sydney. Faculty of Science.Acute, ascending, flaccid motor paralysis of forelimbs and death due to respiratory failure is the dominant characteristic of tick toxicosis by the Australian paralysis tick, Ixodes holocyclus.
Chung, JM
core  

Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels

Basic and Clinical Neuroscience, 2019
Introduction: It is a long time that natural toxin research is conducted to unlock the medical potential of toxins. Although venoms-toxins cause pathophysiological conditions, they may be effective to treat several diseases.
Hanieh Tamadon, Zahra Ghasemi, Fatemeh Ghasemi, Narges Hosseinmardi, Hossein Vatanpour, Mahyar Janahmadi   +5 more
doaj  

Tuning Scorpion Toxin Selectivity: Switching From K_V1.1 to K_V1.3. [PDF]

Front Pharmacol, 2020
Gigolaev AM, Kuzmenkov AI, Peigneur S, Tabakmakher VM, Pinheiro-Junior EL, Chugunov AO, Efremov RG, Tytgat J, Vassilevski AA.   +8 more
europepmc   +1 more source