Results 31 to 40 of about 2,944 (263)
Nuclear Materials and Energy, 2017 Motivated by Radio Frequency (RF) heating studies, the response of the plasma of tokamaks to the presence of a locally polarized limiter is studied. In a first part, we use the TOKAM3X3D global edge turbulence code to analyse the impact of such biasing ...
P. Tamain +10 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of high-field side plasma instabilities in tokamak edge
Nuclear Materials and EnergyBalanced double-null configurations are of general interest for boundary plasma physics, and they have been proposed for some future designs. Experimental observations demonstrate absence of plasma fluctuations in tokamak high-field side scrape-off layer
M.V. Umansky
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Turbulence and transport in spectrally accelerated full-f gyrokinetic simulations
Nuclear FusionWe investigate edge and scrape-off layer (SOL) turbulence and transport using the spectrally accelerated full- f gyrokinetic (GK) code GENE-X , recently introduced in Frei et al (2025 Comput. Phys. Commun. 316 109817).
B.J. Frei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Statistical analysis of plasma filaments in the island divertor of Wendelstein 7-X
Nuclear Fusion, 2023 Plasma filaments have been measured with alkali beam emission spectroscopy in the plasma edge, divertor island, and scrape-off layer of Wendelstein 7-X.
B. Csillag +10 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Nuclear Materials and EnergyAn improved time delay estimation method is used to calculate the velocity of cross-field blob motion in the scrape-off layer of Alcator C-Mod for an ohmic and two high confinement (H-mode) plasmas; an edge localized mode free and an enhanced D-alpha H ...
A.D. Helgeland +3 more
doaj +1 more source