Results 201 to 210 of about 29,784 (268)
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Pathogenesis, detection, and control of scrapie in sheep.
American Journal of Veterinary Research, 2020In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a prion (designated PrPSc). The normal cellular prion protein (PrPC) is encoded by an endogenous gene, PRNP, that is present in high concentrations within the ...
E. Cassmann, J. Greenlee
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Normal host prion protein necessary for scrapie-induced neurotoxicity
Nature, 1996Sebastian Brandner +2 more
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Revue Scientifique et Technique de l'OIE, 1992
A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon.
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Molecular Biotechnology, 1998
Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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Scrapie and other transmissible spongiform encephalopathies (TSEs) are characterized by similar pathology, biochemistry and genetics. The PrP protein and its conversion to the disease-related isoform, PrPSC, are crucial for the development of all TSEs.
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British Medical Bulletin, 1993
There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
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Nature of the Scrapie Agent: Self-replication and Scrapie
Nature, 1967J. Griffith
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Journal of Comparative Pathology and Therapeutics, 1950
Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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Summary Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made.
D R, WILSON, R D, ANDERSON, W, SMITH
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British Veterinary Journal, 1991
Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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Scrapie was first recorded in Cyprus in 1985 in two flocks of sheep and subsequently the disease was diagnosed in dairy goats kept in mixed flocks with affected sheep. By 1989 scrapie had been diagnosed in 23 flocks. Epidemiological data presented in the present study are essentially from clinicopathological investigations between 1985 and 1989.
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