Results 61 to 70 of about 381,300 (337)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Post-deposition heat treatment temperature effect on hydroxyapatite coating [PDF]

MATEC Web of Conferences
This study involved the preparation of hydroxyapatite (HAP) nanoparticle coatings on a Ti6Al4V substrate using electrophoretic deposition (EPD) as the coating technique. Their surface morphology, elemental composition, microstructure, crystalline phases,
Kammoun Jassem, Dhiflaoui Hafedh, Ben Moussa Naoufel   +2 more
doaj   +1 more source

Analysis of material removal process when scratching unidirectional fibers reinforced polyester composites

Science and Engineering of Composite Materials, 2023
In this study, the micromechanical scratch behavior of unidirectional glass fiber reinforced polyester (GFRP) using several wear conditions was highlighted.
Mzali Slah, Elwasli Fatma, Zemzemi Farhat, Mezlini Salah, Mkaddem Ali, Bouazizi Mohamed Lamjed   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Surface Modification of the Ti6Al4V Alloy with Silicon Carbonitride Layer Deposited by PACVD Method

High Temperature Materials and Processes, 2014
Four different layers of various silicon, carbon and nitrogen contents on the Ti6Al4V alloy and (001)Si wafers have been deposited by means of Plasma Assisted Chemical Vapor Deposition (PACVD) method.
Jonas Stanisława, Konefał-Góral Jadwiga, Małek Anna, Kluska Stanisława, Grzesik Zbigniew   +4 more
doaj   +1 more source

Scratch Test Studies on the Connection of Al2O3+40%TiO2 Coating with AZ91 Alloy Casting [PDF]

Archives of Foundry Engineering
The paper presents the results of scratch tests on the connection of the Al2O3+40%TiO2 coating with the AZ91 alloy casting. The Al2O3+40%TiO2 coating was applied to the AZ91 alloy casting using the APS (Atmospheric Plasma Spraying) method. Microstructure
S. Olszewska, M. Mróz
doaj   +1 more source

Microstructural aspects of the protective ceramic coatings applied on the surfaces of refractory alloys produced by additive manufacturing

Manufacturing Review, 2020
The possibility of depositing multi layers made of metals/alloys and high temperature ceramics by electron beam physical evaporation process under high vacuum (EB-PVD) on the surface of a parallelepiped sample made by selective laser melting (SLM) from a
Sobetkii Arcadii, Mosinoiu Laurentiu, Paraschiv Alexandru, Corban Mircea, Piticescu Radu R., Matache Gheorghe   +5 more
doaj   +1 more source

The Unreasonable Effectiveness of Deep Features as a Perceptual Metric

, 2018
While it is nearly effortless for humans to quickly assess the perceptual similarity between two images, the underlying processes are thought to be quite complex.
Efros, Alexei A., Isola, Phillip, Shechtman, Eli, Wang, Oliver, Zhang, Richard   +4 more
core   +1 more source