Results 61 to 70 of about 1,914,471 (291)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Plug flow versus mixed flow modelling of a pressure screen [PDF]
, 2001 The plug flow and mixed flow methods of modelling a screen are analysed in terms of screen length, internal fibre concentration and screen separation performance. Experimental data for consistency changes in screens of narrow length are incorporated into
Walmsley, Michael R.W., Weeds, Zuben
core
Robust High-Quality HfN-HfO 2 Gate Stack for Advanced MOS Device Applications
, 2004 10.1109/LED.2003.820649IEEE Electron Device Letters25270 ...
Kang, J.F. +21 more
core +1 more source
Results in EngineeringThree-dimensional (3D) displays offer the capability to generate lifelike stereoscopic imagery. A defining attribute differentiating 3D from conventional two-dimensional (2D) displays is image authenticity.
Xue Min Sheng +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Immersive sound workshop for Screen South [PDF]
"Learn how to create and exhibit an immersive soundscape with access to Screen South’s Digital Hub, complete with studio space and XR sound facilities to capture foley, narrative, interviews, music, and more.
Masumi, M.
core
Alphaville Journal of Film and Screen Media Podcast. Episode 06, Issue 21, 'Mining Memories'
, 2021 Dr. Gwenda Young, lecturer in FIlm and Screen Media at University College Cork talks with the current Irish Arts Council/UCC Film Artist in Residence Tadhg O'Sullivan about memory, collaboration and process in his film career to ...
Young, Gwenda
core
Nanoscale Research Letters, 2019 How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the ...
Shouhui Chen +8 more
doaj +1 more source