Results 101 to 110 of about 15,735,897 (251)

Recreational screen time and obesity risk in Korean children: a 3-year prospective cohort study

International Journal of Behavioral Nutrition and Physical Activity
Background Studies have shown that prolonged television watching increases obesity risk among children. However, few studies examined the associations with other types of screen time, such as computer and smartphone use, using a prospective cohort study ...
Hajin Jang, Yoonkyoung Cho, Hannah Oh
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study

, 2019
BackgroundPre-school children spend an average of two-hours daily using screens. We examined associations between screen-time on pre-school behavior using data from the Canadian Healthy Infant Longitudinal Development (CHILD) study.MethodsCHILD ...
Victor Ezeugwu (6597683), Joyce Chikuma, Sukhpreet K Tamana, Theo J Moraes, Diana L. Lefebvre (5585027), Sukhpreet K. Tamana (6597680), Allan B. Becker (128031), Meghan B. Azad (320041), Carmen Rasmussen, Carmen Rasmussen (2541397), Padmaja Subbarao, Theo J. Moraes (301657), Stuart E. Turvey (231374), Piush J. Mandhane (4164349), CHILD study Investigators, Padmaja Subbarao (283228), Jacqueline Pei, Valerie Carson (202243), Meghan B Azad, Jacqueline Pei (6597692), Victor Ezeugwu, Piush J Mandhane, Bruce D. Dick (6597689), Diana L Lefebvre, Malcolm R Sears, Valerie Carson, Stuart E Turvey, Bruce D Dick, Allan B Becker, Malcolm R. Sears (4164352), Joyce Chikuma (6597686)   +30 more
core   +1 more source

Can leisure education effect on screen time and perceived leisure benefits for college students?

Frontiers in Psychology
BackgroundSince children and adolescents usually spend their theoretical course time at schools, they experience many negative effects of inactivity and physical inactivity. They are disadvantaged in terms of facing many health and social problems due to
Abdullah Bora Özkara, Olcay Mulazimoglu, Mustafa Baris Somoglu, Fatih Kirkbir, Erdi Tokul, Burakhan Aydemir, Halil Evren Senturk, Ibrahim Dalbudak, Ozgun Mirac Ozcilingir   +8 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

IoT-Enabled Intelligent Health Care Screen System for Long-Time Screen Users

Engineering Proceedings
With the rapid rise in technological advancements, health can be tracked and monitored in multiple ways. Tracking and monitoring healthcare gives the option to give precise interventions to people, enabling them to focus more on healthier lifestyles by ...
Subramanian Vijayalakshmi, Joseph Alwin, Jayabal Lekha   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An Adaptive Acceleration Structure for Screen-space Ray Tracing

, 2015
We propose an efficient acceleration structure for real-time screenspace ray tracing. The hybrid data structure represents the scene geometry by combining a bounding volume hierarchy with local planar approximations.
Pajak, D., Luebke, D., Kautz, J., Goesele, M., Schulz, A., Widmer, S., Pulli, K.   +6 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source