Results 111 to 120 of about 15,735,897 (251)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pandemic-related anxiety and screen time: A mediation analysis

Journal of Affective Disorders Reports
Background: The COVID-19 pandemic brought worldwide lockdowns and social distancing, causing feelings of pandemic-related anxiety and consequentially poorer mental health and loneliness.
Hailey Burns, Abiaz Hossain, Alyssa Forbes, Sana Sheikh, Ravishankar Subramani Iyer, Silvia Marin-Dragu, Davi Pereira dos Santos, Rita Orji, Tomas Hajek, Sherry Stewart, Alexa Bagnell, Sandra Meier   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Change in screen time and overuse, and their association with psychological well-being among US-wide school-age children during the COVID-19 pandemic: analysis of the National Survey of Children’s Health (NSCH) years 2018–21

Child and Adolescent Psychiatry and Mental Health
Background Previous studies on screen use and children’s mental health during the Coronavirus Disease 2019 (COVID-19) pandemic focused only on the timeframe during the pandemic, on children between narrow age ranges, only among a subset of children who ...
Helena T. Wu, Jiandong Li, Amy Tsurumi
doaj   +1 more source

The Relationship Between Screen Time, Sleep and Obesity

Journal of Education, Health and Sport
Introduction Excessive screen time has emerged as a major public health concern, particularly due to its association with sleep disturbances and the rising prevalence of obesity.
Dominika Lewandowska, Dominika Rosińska-Lewandoska, Zofia Podraza, Dominika Strep, Julia Grabowska, Jakub Rosiński, Zofia Głowniak, Maciej Kwiatkowski, Izabela Kwiatkowska, Malwina Soja   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Commentary: Screening of screen time in children

Indian Journal of Ophthalmology, 2022
Ashwin Sainani
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development and application of the phase-screen seismic modelling code [PDF]

, 2009
As a consequence of the aims of this project, this thesis is divided into two distinct sections. Initially, the computationally efficient phase-screen forward modelling technique is extended to allow investigation of non-normal ray paths.
White, James C.
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