Results 281 to 290 of about 2,642,234 (338)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Longitudinal changes in screen time, sleep, and sports/exercise activity in early adolescence. [PDF]

BMC Pediatr
Nagata JM, Helmer CK, Memon Z, Ramappa S, Wong JH, Diep T, Al-Shoaibi AA, Ganson KT, Testa A, Baker FC, Gabriel KP, Dooley EE.   +11 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Association between screen time and non-suicidal self-injury among adolescents: a compositional isotemporal substitution analysis. [PDF]

Front Public Health
Xu W, Guo H, Jiang K, Shi H, Wang S, Tang X, Hu Z, Man M, Ruan W, Geng A, Qu G, Zhang Z.   +11 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Preterm-born children, screen time, and spectacle wear in the Longitudinal Preterm Outcome Project: a cohort study

Vasanthi Iyer, Marlou L. A. de Kroon, Caroline C. W. Klaver, Sijmen A. Reijneveld   +3 more
openalex   +1 more source

Temporal patterns of adolescent screen time and compulsive internet use in Moroccan high school students. [PDF]

Addict Behav Rep
Imrani S, Touri B, Romo L, Zerhouni O.
europepmc   +1 more source

Adiposity and attention deficit hyperactivity disorder comorbidity in Chinese children and adolescents: the role of adiposity duration and screen time. [PDF]

BMC Pediatr
Bai D, Gu Q, Shen F, Suo G, Zheng Y, Li H, Wang H, Cai J, Wu Y.   +8 more
europepmc   +1 more source

Screen Time and Sleep Bruxism-A Comparison Between the Present Time and the COVID-19 Pandemic. [PDF]

Children (Basel)
Mitova N, Dimitrova M.
europepmc   +1 more source

The hidden costs of screen time: altered brain network efficiency in children with autism spectrum disorder. [PDF]

BMC Psychiatry
Xue Y, Zhang Y, Bai M, Dong H, Feng J, Jia FY.   +5 more
europepmc   +1 more source