Results 91 to 100 of about 252,487 (303)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Educational Screening and Occupational Earnings [PDF]
The educational screening hypothesis states that beyond a certain point schooling functions as a signaling device to identify pre-existing talents. We test for the presence of screening by comparing the schooling and earnings of self-employed workers and
Joel Hay, Edward N. Wolff
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A 3D Bioprinted Hydrogel Microfluidic Device for Screening Applications [PDF]
, 2023 The microfluidic enabled the integration of engineered miniaturized tissue models for drug screening. Conventional polydimethylsiloxane or plastic-based devices require multiple fabrication steps, which are challenging.
Bhusal, Anant
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae [PDF]
, 2017 Movement response of zebrafish to chemicals is of interest in screening studies. We introduce a microfluidic device for partial immobilization, headl-arginine exposure and movement screening of zebrafish larvae under controlled conditions.
Pouya Rezai +3 more
core +1 more source
BMC Health Services ResearchBackground/objectives Visual Electro-Diagnostic Testing (EDTs) are a highly specialised service in the NHS. The high cost of tests and a paucity of trained visual electrophysiologists has resulted in very few services across the UK and, when combined ...
Steffen Bayer +9 more
doaj +1 more source
Vision screening using the Acuidrive device
Clinical and Experimental OptometryUnderstanding devices used for vision screening, including their potential utilisation and validity, will facilitate proper utilisation of this technology.The Acuidrive is a self-illuminated, hand-held, visual acuity screening device intended for use in policing, with visual acuity assessed roadside to identify drivers who may not meet vision standards
David A Atchison +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The probationary period as a screening device: competitive markets [PDF]
, 2006 Seminal papers about asymmetry of information in a competitive insurance market, and the monetary deductible as a screening device show that any existing equilibrium is of a separating type.
Karlsson, M., Spreeuw, J.
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