Results 111 to 120 of about 252,487 (303)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The PRIS-Tool. A simple screening device for eye care

Current Directions in Biomedical Engineering
With the PRIS-Tool we aim to enable a fast, simple and stable eye self-screening that makes pathological changes in the retinal blood vessels visible to the patient.
Tautorat Carsten, Grabow Niels, Schmidt Wolfram, Guthoff Rudolf, Stahnke Thomas, Lips Thomas, Senz Volkmar, Lebahn Kerstin   +7 more
doaj   +1 more source

The Persian Self-Report Version of the Antisocial Process Screening Device (APSD-P): A Psychometric Evaluation. [PDF]

Front Psychiatry, 2021
Ebrahimi A, Elhami Athar M, Darvishi M, Colins OF.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma : a systematic review and economic evaluation [PDF]

, 2007
Objectives: To assess whether open angle glaucoma (OAG) screening meets the UK National Screening Committee criteria, to compare screening strategies with case finding, to estimate test parameters, to model estimates of cost and cost-effectiveness, and ...
Ramsay, Craig R, Burr, JM, Fraser, Cynthia Mary, Siddiqui, M.A.R., Cook, Jonathan Alistair, C Ramsay, S McPherson, Vale, L., R Wormald, Fraser, C., Wormald, R, K Rabindranath, Wormald, R., Lourenco, T, Ramsay, C, Grant, A, Cook, J, Mowatt, G, Fraser, C, Deeks, J, J Burr, Hernández, R, Cook, J., Vale, L, Burr, Jennifer Margaret, Burr, J.M., Hernández, R., Azuara-Blanco, A, Azuara-Blanco, Augusto, Hernández, Rodolfo Andrés, Vale, Luke David, Deeks, J., Mowatt, Graham, Azuara-Blanco, A.; id_orcid, McPherson, S, L Vale, A Azuara-Blanco, McPherson, S., M Siddiqui, T Lourenco, Mowatt, G., R Hernández, Grant, A., Rabindranath, K., C Fraser, J Cook, Lourenco, Tania, Grant, Adrian Maxwell, Cairns, J, Siddiqui, Muhammad Ardul Rehman, Cairns, J., Azuara-Blanco, A., J Deeks, Rabindranath, K, Ramsay, C., Burr, J M, Siddiqui, MA, Siddiqui, MAR, A Grant, Lourenco, T., G Mowatt, Siddiqui, M A R, J Cairns   +62 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

RETURNS TO SCHOOLING: SKILLS ACCUMULATION OR INFORMATION REVELATION? [PDF]

This paper explores the degree to which imperfect information in the labour market regarding worker quality is likely to impact employment opportunities, as well as the wages associated with those opportunities.
S. Ssekabira Ntege, Steven F. Koch
core   +3 more sources

ZEUS (ZIF-based electrochemical ultrasensitive screening) device for isopentane analytics with focus on lung cancer diagnosis. [PDF]

RSC Adv, 2021
Banga I, Paul A, Sardesai AU, Muthukumar S, Prasad S.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Targeted Screening for Cancer: Learnings and Applicability to Melanoma: A Scoping Review [PDF]

This scoping review aims to systematically gather evidence from personalized cancer-screening studies across various cancers, summarize key components and outcomes, and provide implications for a future personalized melanoma-screening strategy.
Amelia K. Smit, Lejie Zheng, Monika Janda, Anne E. Cust   +3 more
core   +1 more source