Results 101 to 110 of about 252,487 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cost-effectiveness of adding Endocuff® to standard colonoscopies for interval colorectal cancer screening

ClinicoEconomics and Outcomes Research, 2019
Tiffany M Yu,1 Alison Tradonsky,1 Jun Tang,1 Renée JG Arnold1,21Department of Life Sciences, Navigant Consulting, Inc, San Francisco, CA, USA; 2Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New ...
Yu TM, Tradonsky A, Tang J, Arnold RJG
doaj  

Evaluation of an Investigational Hearing Screening Device (HeLe) to Demonstrate Acoustic Brainstem Response among Normal-hearing Adults. [PDF]

Acta Med Philipp, 2023
Fullante PB, Labra PJP, Mauricio JMA, Luistro AR, Marcelo PGF, Sison LG, Chiong CM.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Electrochemical peroxidation of contaminated water and assessment of the toxicity using existing and novel bioassays [PDF]

, 2011
The treatment of wastewater and monitoring of its toxicity is essential before discharging it to the environment. This study focuses on assessing the toxicity of wastewater following treatment using the electrochemical peroxidation process (ECP). Three
Kokkali, Varvara
core  

Usability Evaluation of a Noninvasive Neutropenia Screening Device (PointCheck) for Patients Undergoing Cancer Chemotherapy: Mixed Methods Observational Study. [PDF]

J Med Internet Res, 2022
Lamaj G, Pablo-Trinidad A, Butterworth I, Bell N, Benasutti R, Bourquard A, Sanchez-Ferro A, Castro-Gonzalez C, Jiménez-Ubieto A, Baumann T, Rodriguez-Izquierdo A, Pottier E, Shelton A, Martinez-Lopez J, Martinez-Lopez J, Sloan JM.   +15 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Venture Cycles: Theory and Evidence [PDF]

We demonstrate how endogenous information acquisition in venture capital markets creates investment cycles when competing financiers undertake their screening decisions in an uncoordinated way, thereby highlighting the role of intertemporal screening ...
Rune Stenbacka, Thomas Gehrig
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evaluating the Detection Performance of a Drug Screening Device

Measurement Science Review
This study focuses on detecting addictive substances in the human body using modern instrumental methods, specifically the Dräger DrugTest 5000 (DDT 5000) device.
Král Luděk, Tesař Jiří
doaj   +1 more source