Results 101 to 110 of about 18,538,278 (363)

Screening performance of COPD-PS scale, COPD-SQ scale, peak expiratory flow, and their combinations for chronic obstructive pulmonary disease in the primary healthcare in Haicang District, Xiamen City

Frontiers in Medicine
ObjectivesThis study aimed to evaluate the screening performance of COPD-PS questionnaire, COPD-SQ questionnaire, peak expiratory flow (PEF), COPD-PS questionnaire combined with PEF, and COPD-SQ questionnaire combined with PEF for chronic obstructive ...
Xueting Shen, Hua Yang, Chengdian Lan, Fen Tang, Qinfei Lin, Yingjie Chen, Jinxiang Wu, Xionghua Chen, Zhigang Pan   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Verfahrensdokumentation für NPO-11: Screening zur Einschätzung des psychosozialen Nachsorgebedarfs in der pädiatrischen Onkologie [PDF]

Der NPO-11 dient als Screening zur Einschätzung des psychosozialen Nachsorgebedarfs in der pädiatrischen Onkologie im Selbst- und Elternbericht. Anhand von Expertenangaben wurden jeweils 11 Items für die Nachsorgebereiche Progredienzangst, Traurigkeit ...
Kamm-Thonwart, R., Hoffmann, R., Kulisch, L., Schepper, F., Jäschke, Y., Martini, J., Herrmann, J., Herzog, K., Graf Einsiedel, H.   +8 more
core   +1 more source

Routine first-trimester screening for fetal trisomies in twin pregnancy: cell-free DNA test contingent on results from combined test [PDF]

, 2018
Objective: To report on the routine clinical implementation of cell-free (cf)DNA analysis of maternal blood for trisomies 21, 18 and 13 contingent on the results of the first-trimester combined test in twin pregnancies.
Gil Mira, María del Mar, Gil, M.M., Nicolaides, Kypros H., Galeva, S., Akolekar, R., Nicolaides, K.H., Akolekar, Ranjit, Konstantinidou, L., Konstantinidou, Liountmila, Galeva, Slavyana   +9 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Is ultrasound screening for vasa praevia clinically justified and a financially viable screening test? A literature review [PDF]

, 2018
Vasa praevia is an obstetric complication currently not screened for within the United Kingdom, which if undetected prenatally can lead to fetal death when the membranes rupture.
Heather Venables, Gillian Coleman
core   +1 more source

Distribution and Genetic Characterization of the MNS Blood Group in Multi-Ethnic Populations of East China

Journal of Blood Medicine
Zihao Xu,1,* Zhihong Fang,2,* Rong Lu,1 Jia Jiang,1 Shuhong Xie,3 Mingyuan Wang,1 Yiming Jin,1 Zhen Liu1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Laboratory Medicine ...
Xu Z, Fang Z, Lu R, Jiang J, Xie S, Wang M, Jin Y, Liu Z   +7 more
doaj  

Guideline for screening and diagnosing gestational diabetes mellitus [PDF]

, 2015
Gestational diabetes mellitus (GDM) is on the rise, especially with the increase in obesity in childbearing women as well as the rising prevalence of diabetes mellitus type 2.
Craus, Johann, Savona-Ventura, Charles, Cuschieri, Sarah   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source