Results 31 to 40 of about 684,789 (267)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Training in Group Decision Making in Situational Training Centers

open access: yesПсихолого-педагогические исследования, 2018
The article deals with the psychological and pedagogical problems of training situational centers (TSC) as a learning environment for group decision-making.
Mitin A.I.
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Récits de marque en contexte collaboratif

open access: yesCommunication, 2015
This research brief sheds some new light on the interplay of factors influencing brand marketing. The authors examine how the connotations attached to brand names in two holiday travel promotions evolve in parallel with particularly inventive accounts of
Cécile McLaughlin   +2 more
doaj   +1 more source

Transition to Retirement for Older People with Intellectual Disabilities—Staff Descriptions of the Process and Roles

open access: yesScandinavian Journal of Disability Research, 2023
Our study examines how staff in housing and day activity centres describe the transition of people with intellectual disabilities (ID) to old-age retirement.
Sirpa Granö   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Fotografía y conocimiento de la biodiversidad: El uso de la imagen en la conservación

open access: yesMètode Science Studies Journal: Annual Review
Desde sus comienzos, la fotografía tuvo un importante protagonismo como herramienta documental. Fue utilizada como instrumento en la comunicación y difusión de proyectos de investigación y conservación de la biodiversidad en distintas partes del planeta.
Santiago Carreira
doaj   +1 more source

COGNITIVE AND PRAGMATIC MECHANISMS OF GENERATING SITUATIONAL AND ECHOIC IRONY (A CASE STUDY OF THACKERAY’S NOVEL THE HISTORY [PDF]

open access: yesAlfred Nobel University Journal of Philology
The aim of the article is to identify the cognitive and pragmatic mechanisms of irony generation in Thackeray’s Novel, The History of Pendennis: His Fortunes and Misfortunes, His Friends and His Greatest En- emy, while distinguishing between ...
Nataliia N. Kravchenko   +1 more
doaj   +1 more source

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