Results 41 to 50 of about 684,789 (267)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Una imagen y mil palabras: El binomio fotografía y ciencia
Mètode Science Studies Journal: Annual ReviewLa fotografía nace a principios del siglo XIX como una herramienta con la que retratar el mundo que nos rodea. Con su aparición, la comunidad científica encontró una aliada con la que traspasar las fronteras del conocimiento.
Roberto García-Roa
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Texture for script identification [PDF]
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2005 The problem of determining the script and language of a document image has a number of important applications in the field of document analysis, such as indexing and sorting of large collections of such images, or as a precursor to optical character recognition (OCR). In this paper, we investigate the use of texture as a tool for determining the script
Andrew Busch +2 more
openaire +3 more sources
3arabizi - When Local Arabic Meets Global English
Acta Linguistica Asiatica, 2012 Arabic is the official language of Jordan. Yet, English is a language of prestige among many upwardly mobile Jordanians. Sakarna (2006) dubs a hybrid language comprised of a mixture of these two languages “Englo-Arabic”.
Robert Michael BIANCHI
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Topics in Language Disorders, 2016 Purpose: Script training for aphasia involves repeated practice of relevant phrases and sentences that, when mastered, can potentially be used in other communicative situations. Although an increasingly popular approach, script development can be time-consuming.
Rosalind C, Kaye, Leora Reiff, Cherney
openaire +2 more sources
Language 4R: Discussing the Roots of Language Identity in the African American Community
Modern Languages OpenThis article presents language reparation/reappropriation/reclamation/restoration, or language 4R for brevity’s sake, as a proposed mode of discourse dedicated to the roles of language in healthy constructions of African American identity.
Kyra Ann Dawkins
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source