Results 31 to 40 of about 198,576 (265)

Typographic Reification: Instantiations from the Lucy Lloyd Archive and Contemporary Typefaces from Southern Africa

open access: yesArts, 2019
This paper argues that we may read the images from the Lucy Lloyd archive of ancient Khoe and San symbols, drawings and pictograms in a special way that offers an intellectual seriousness to these collaborative picture-word creations that attempted to ...
Kurt Campbell
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Humour of Bruca Braca Bruda Brada

open access: yesThe European Journal of Humour Research
This article is about the Bosnian animated series Bruca Braca Bruda Brada which deals with contemporary social issues in Bosnia and Herzegovina, focusing on Švrakino selo, a predominantly working-class neighbourhood on the outskirts of Sarajevo.
Selma Đuliman, Matija Bošnjak
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Positive Emotions and Entrepreneurial Intention: The Mediating Role of Entrepreneurial Cognition

open access: yesFrontiers in Psychology, 2021
Under the background of “mass entrepreneurship and innovation,” entrepreneurship and innovation for college students not only alleviates the current social employment pressure but also sets off the upsurge of their entrepreneurship.
Ben-Song Chen   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Masculinity Beyond Repair: Aging, Pathology, and the Male Body in Jonathan Franzen’s The Corrections

open access: yesAnafora, 2019
This article explores representations of male aging in Jonathan Franzen’s The Corrections (2001) by looking at theories of aging, pathology, and hegemonic masculinity.
Stela Dujaković
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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