Results 41 to 50 of about 929,025 (292)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Typographic Reification: Instantiations from the Lucy Lloyd Archive and Contemporary Typefaces from Southern Africa

open access: yesArts, 2019
This paper argues that we may read the images from the Lucy Lloyd archive of ancient Khoe and San symbols, drawings and pictograms in a special way that offers an intellectual seriousness to these collaborative picture-word creations that attempted to ...
Kurt Campbell
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The 'ideal square' of logographic scripts and the structural similarities of Khitan script and han'gul [PDF]

open access: yes, 2002
A comparison of the Khitan Small Script and Korean han'gŭl shows a striking structural similarity of two essentially phonetic scripts that combine 'letters' into large blocks.
Tranter, Nicolas
core  

Script Identification of Multi-Script Documents: a Survey

open access: yesIEEE Access, 2017
In recent years, with the widespread of Internet and digitized processing of multi-script documents worldwide, script identification techniques have become more important in the pattern recognition field. Script identification concerns methods for identifying different scripts in multi-lingual, multi-script documents.
Kurban Ubul   +5 more
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Humour of Bruca Braca Bruda Brada

open access: yesThe European Journal of Humour Research
This article is about the Bosnian animated series Bruca Braca Bruda Brada which deals with contemporary social issues in Bosnia and Herzegovina, focusing on Švrakino selo, a predominantly working-class neighbourhood on the outskirts of Sarajevo.
Selma Đuliman, Matija Bošnjak
doaj   +1 more source

Positive Emotions and Entrepreneurial Intention: The Mediating Role of Entrepreneurial Cognition

open access: yesFrontiers in Psychology, 2021
Under the background of “mass entrepreneurship and innovation,” entrepreneurship and innovation for college students not only alleviates the current social employment pressure but also sets off the upsurge of their entrepreneurship.
Ben-Song Chen   +3 more
doaj   +1 more source

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