Results 51 to 60 of about 929,025 (292)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Masculinity Beyond Repair: Aging, Pathology, and the Male Body in Jonathan Franzen’s The Corrections

open access: yesAnafora, 2019
This article explores representations of male aging in Jonathan Franzen’s The Corrections (2001) by looking at theories of aging, pathology, and hegemonic masculinity.
Stela Dujaković
doaj   +1 more source

Data management and analysis with WRF and SFIRE

open access: yes, 2012
We introduce several useful utilities in development for the creation and analysis of real wildland fire simulations using WRF and SFIRE. These utilities exist as standalone programs and scripts as well as extensions to other well known software.
Beezley, Jonathan   +4 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Hierarchical Quantized Representations for Script Generation

open access: yes, 2018
Scripts define knowledge about how everyday scenarios (such as going to a restaurant) are expected to unfold. One of the challenges to learning scripts is the hierarchical nature of the knowledge.
Balasubramanian, Niranjan   +3 more
core   +1 more source

InfoLink: analysis of Dutch broadcast news and cross-media browsing [PDF]

open access: yes, 2005
In this paper, a cross-media browsing demonstrator named InfoLink is described. InfoLink automatically links the content of Dutch broadcast news videos to related information sources in parallel collections containing text and/or video.
Hessen, Arjan van   +3 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Unveiling the unseen: the challenge of phenomenological conceptual untranslatables

open access: yesСлово.ру: балтийский акцент
This article aims to explore the significant challenges posed by phenomenological un­translatables while also emphasizing their role as cultural phenomena. Phenomenological untranslatables are typically associated with a specific cultural, historical, or
Vera I. Zabotkina, Elena L. Boyarskaya
doaj   +1 more source

Deep Learning Approaches for Nusantara Scripts Optical Character Recognition

open access: yesIJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2023
The number of speakers of regional languages who are able to read and to write traditional scripts in Indonesia is decreasing. If left unaddressed, this will lead to the extinction of Nusantara scripts and it is not impossible that their reading methods ...
Agi Prasetiadi   +3 more
doaj   +1 more source

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