Results 41 to 50 of about 919,668 (268)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Positive Emotions and Entrepreneurial Intention: The Mediating Role of Entrepreneurial Cognition

open access: yesFrontiers in Psychology, 2021
Under the background of “mass entrepreneurship and innovation,” entrepreneurship and innovation for college students not only alleviates the current social employment pressure but also sets off the upsurge of their entrepreneurship.
Ben-Song Chen   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Second Stage of the “Religious Revival” in Russia: How to Evaluate It from the Perspective of the Secularization Debate

open access: yesReligions
This article focuses on the religious processes in Russia over the last fifteen years. The author has two objectives: on the one hand, to describe processes that can be called the second stage of the “religious revival” in contemporary Russia, and on the
Dmitry Uzlaner
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Data management and analysis with WRF and SFIRE

open access: yes, 2012
We introduce several useful utilities in development for the creation and analysis of real wildland fire simulations using WRF and SFIRE. These utilities exist as standalone programs and scripts as well as extensions to other well known software.
Beezley, Jonathan   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Masculinity Beyond Repair: Aging, Pathology, and the Male Body in Jonathan Franzen’s The Corrections

open access: yesAnafora, 2019
This article explores representations of male aging in Jonathan Franzen’s The Corrections (2001) by looking at theories of aging, pathology, and hegemonic masculinity.
Stela Dujaković
doaj   +1 more source

Guide to handling test papers and scripts (Key stage 2, years 3–6: English and mathematics) [PDF]

open access: yes, 2011
"The Guide to handling test papers and scripts is for headteachers, test administrators and key stage 2 assessment and special needs coordinators... [It] provides guidance on handling, packaging and labelling test materials, attendance registers and ...

core  

FixMiner: Mining Relevant Fix Patterns for Automated Program Repair [PDF]

open access: yes, 2019
Patching is a common activity in software development. It is generally performed on a source code base to address bugs or add new functionalities. In this context, given the recurrence of bugs across projects, the associated similar patches can be ...
Bissyandé, Tegawendé F.   +6 more
core   +2 more sources

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