Results 261 to 270 of about 183,994 (309)

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Multiplets in scRNA-seq data: Extent of the problem and efficacy of methods for removal. [PDF]

PLoS One
Ttoouli D, Hoffmann D.
europepmc   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

A hybrid neighborhood enhanced contrastive learning and self-knowledge distillation method for scRNA-seq data clustering analysis. [PDF]

Bioinformatics
Qi L, Wang P, Liu H, Chen C, Gu J, Chen C.   +5 more
europepmc   +1 more source

Preliminary Analysis of the Proportion and Characteristics of Dual BCR B Cells in SLE Model Mice and Patients via scRNA-Seq Combined with scBCR-Seq Technology. [PDF]

Cells
Quan K, Yang H, Tang G, Li Z, Zou H, Ma J, Yao X.   +6 more
europepmc   +1 more source

scANMF: Prior Knowledge and Graph-Regularized NMF for Accurate Cell Type Annotation in scRNA-seq. [PDF]

Int J Mol Sci
Chi W, Zheng Y, Fang H, Shi S.
europepmc   +1 more source

scSuperAnnotator: a platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data. [PDF]

Nucleic Acids Res
Qi Q, Su Y, Fan Y, Yu Z, Huang Y, Wong KC, Li X.   +6 more
europepmc   +1 more source

Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice. [PDF]

Nucleic Acids Res
Gao H, Yang S, Ning A, Yin L, Lan Y, Cheng K, Xiong W, Xiong X, Zhang J, Chen J, Feng S, Fan X, Liu K, Gui Y, Zhang P, Wang X, Wang F, Chen X, Zhang Q, Yuan S.   +19 more
europepmc   +1 more source

CoPhaser: generic modeling of biological cycles in scRNA-seq with context-dependent periodic manifolds

Paychère Y, Salati A, Gobet C, Naef F.
europepmc   +1 more source