Results 251 to 260 of about 86,859 (350)

Integration of scRNA-Seq and bulk RNA-Seq to Establish a Macrophage-related Prognostic Model in Ovarian Cancer [PDF]

Changyuan Yu, Guangji Yang, Dongyan Ren, Yantao Li, Chong Yue, Qin Yang, Jie Zhang   +6 more
openalex   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Systematic scRNA-seq screens profile neural organoid response to morphogens. [PDF]

Nat Methods
Sanchís-Calleja F, Azbukina N, Jain A, He Z, Okamoto R, Rusimbi C, Rifes P, Rathore GS, Santel M, Janssens J, Seimiya M, Eisinger B, Fleck JS, Kirkeby A, Camp JG, Treutlein B.   +15 more
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

The performance of Federated Harmony on two scRNA-seq data.

Ruizhi Yuan (16864629), Ziqi Rong (22339789), Haoran Hu (6032510), Tianhao Liu (4678147), Shiyue Tao (11871368), Wei Chen (23863), Lu Tang (655389)   +6 more
openalex   +1 more source

PBMCpedia: a harmonized PBMC scRNA-seq database with unified mapping and enhanced celltype annotation. [PDF]

Nucleic Acids Res
Hoffmann ES, Hombrecher L, Diks IF, Flotho M, Hirsch P, Keller A, Grandke F.   +6 more
europepmc   +1 more source

Evaluation of the performance of PaaSc on 136 annotated scRNA-seq datasets.

Xiqi Liao (22593395), Yuyang Hong (22593398), Yan Feng (128912), Henghui Li (547700), Hai Fang (160549), Jiantao Shi (70432)   +5 more
openalex   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

Advanced Science, EarlyView.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng, Fuze Cong, Shenbo Zhang, Rui Lv, Wenjia Zhang, Xinyi Ke, Juncheng Wu, Zhonghe Zhao, Kui Zhao, Di Dong, Ruofan Zhang, Zhengyu Jin, Max Seidensticker, Zhiwei Wang, Huanwen Wu, Xianlin Han, Nan Hong, Huadan Xue   +17 more
wiley   +1 more source

Image 2_Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning.tif

Xianchang Zeng (9329117), Lingyun Wei (2658940), Lu Lv (151811), Di Wu (23906), Yingying Shen (451840), Xinliang Lu (11797748), Xianghui Kong (810085), Zhijian Cai (117323), Jianli Wang (1305390)   +8 more
openalex   +1 more source

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis [PDF]

, 2019
Cole, M, Gross, CC, Hartlehnert, M, Heming, M, Lautwein, T, Meuth, SG, Schafflick, D, Schulte-Mecklenbeck, A, Wiendl, H, Xu, CA, Yosef, N, zu Hoerste, G Meyer   +11 more
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