Results 291 to 300 of about 86,859 (350)

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Parental Specific Expression by scRNA-Seq Reveals HaWRKY40 Contributing to Heterosis of Sunflower. [PDF]

Plant Biotechnol J
Han Y, Zhang J, Cai M, Zhang S, Dai W, Lei Z, Huang Q, Xiang L, Chen T.   +8 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

ScRNA-seq reveals dynamic macrophage heterogeneity in chronic liver disease progression and prognostic biomarkers <i>KLF2/SPP1</i> in HCC. [PDF]

Front Immunol
Pan Q, Wang X, Li B, Cai Z, Chen S, Hu J, Yuan X, Yang J, Guo AY, Zhang Z.   +9 more
europepmc   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

D3Impute: Dropout-aware discrimination, distribution-aware modeling, and density-guide imputation for scRNA-seq data. [PDF]

PLoS Comput Biol
Huang S, Jiang L, Yi M, Zhu Y.
europepmc   +1 more source

Summary of GWAS, eQTL, RNA-seq, scRNA-seq, and Drug Database Resources Used for Hypothyroidism and Cirrhosis Research.

Ziyang Yang (9190108), Weixuan Liang (14518362), Qi Zhang (28502), Can Weng (10917064), Hao Deng (409186), Zhuofeng Wen (22582266), Jingyi Wu (1472761), Jingwen Deng (1453663), Zhixin Xie (2732), Yiwei Lin (398586), Xiuling Fu (12981392), Chengxin Gu (8521758), Tao Yang (184280), Hui Yang (91136), Jiyuan Zhou (531978)   +14 more
openalex   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Tumor heterogeneity assessment using single-cell RNA sequencing (scRNA-seq): applications in lung cancer for diagnosis and treatment. [PDF]

Front Immunol
Bica C, Zanoaga O, Pop L, Ciocan C, Raduly L, Nuțu A, Berindan-Neagoe I, Bender A.   +7 more
europepmc   +1 more source