Results 61 to 70 of about 183,994 (309)
Clinical and Translational Medicine, 2021 scRNA‐seq is on track for use as a routine measurement of clinical biochemistry and to assist in clinical decision‐making and guide the performance of molecular medicine, but there are still a large number of challenges to be overcome.
Hao Fang +5 more
doaj +1 more source
scRNA-seq of 5 cell lines using 10x v3 kit
, 2019 scRNA-seq of 5 lung cancer cell lines (A549, H838, HCC827, H1975, H2228) using 10x v3 kit. previous study: https://www.nature.com/articles/s41592-019-0425-8scRNA-seq data processed by cellranger (3.0.2).
MATTHEW RITCHIE (1135550) +1 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Frontiers in Toxicology, 2022 In this report, we compare the outcomes and limitations of two methods of transcriptomic inquiry on adult zebrafish testes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during sexual differentiation: conventional or bulk RNA-seq (bulk-seq) and ...
Alex Haimbaugh +8 more
doaj +1 more source
scRNA-seq analyses of CD8+ T cells responding to acute vs. chronic infection.
, 2023 (A) Experimental setup. CD8+CD45.1+ P14 T cells were adoptively transferred into separate CD45.2+ hosts 1 day prior to infection with either LCMV-Arm or LCMV-Cl13.
Lara Labarta-Bajo (9096773) +14 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
TMExplorer: A tumour microenvironment single-cell RNAseq database and search tool
PLoS ONE, 2022 Motivation The tumour microenvironment (TME) contains various cells including stromal fibroblasts, immune and malignant cells, and its composition can be elucidated using single-cell RNA sequencing (scRNA-seq).
Erik Christensen +4 more
doaj +3 more sources
(Preprint) Sort-Seq: immune repertoire-based scRNA-Seq systematization
, 2023 The functional programs chosen by B and T cell clones fundamentally determine the architecture of immune response to distinct challenges. Advances in scRNA-Seq have improved our understanding of the diversity and stability of these programs, but it has ...
Valeriia Kriukova (13040013)
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
Frontiers in Immunology, 2021 Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the ...
Binyao Chen +3 more
doaj +1 more source