Results 61 to 70 of about 221,267 (266)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing

Frontiers in Immunology, 2021
Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the ...
Binyao Chen, Lei Zhu, Shizhao Yang, Wenru Su   +3 more
doaj   +1 more source

scRNA-Seq of mouse immortalized aortic smooth muscle cells treated with IL1b

, 2022
Methods Mouse immortalized aortic smooth muscle cells (MOVAS; ATCC cell line CRL-2797) were grown in DMEM supplemented with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin and 200 μg/ml geneticin in a 37 °C incubator with 5% CO2.
Minna U. Kaikkonen (193048), Tiit Örd (10716138), Kadri Õunap (462157)   +2 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

Advanced Science
Emerging single‐cell sequencing technology has generated large amounts of data, allowing analysis of cellular dynamics and gene regulation at the single‐cell resolution.
Pengfei Wang, Wenhao Liu, Jiajia Wang, Yana Liu, Pengjiang Li, Ping Xu, Wentao Cui, Ran Zhang, Qingqing Long, Zhilong Hu, Chen Fang, Jingxi Dong, Chunyang Zhang, Yan Chen, Chengrui Wang, Guole Liu, Hanyu Xie, Yiyang Zhang, Meng Xiao, Shubai Chen, Haiping Jiang, The X‐Compass Consortium, Yiqiang Chen, Ge Yang, Shihua Zhang, Zhen Meng, Xuezhi Wang, Guihai Feng, Xin Li, Yuanchun Zhou   +29 more
doaj   +1 more source

Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database.

PLoS Computational Biology, 2018
As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the number of tools designed to analyse these data has dramatically increased.
Luke Zappia, Belinda Phipson, Alicia Oshlack   +2 more
doaj   +1 more source

Merged Adult Human Kidney scRNA-seq dataset

, 2021
A merged human kidney scRNA-seq dataset made from the following scRNA-seq studies: Menon et al. Lake et al. Wu et al. Liao et al.
Fadhl Alakwaa, Adam Tisch, Stephen Blough   +2 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

The molecular landscape of neurological disorders: insights from single-cell RNA sequencing in neurology and neurosurgery

European Journal of Medical Research, 2023
Single-cell ribonucleic acid sequencing (scRNA-seq) has emerged as a transformative technology in neurological and neurosurgical research, revolutionising our comprehension of complex neurological disorders.
Wireko Andrew Awuah, Arjun Ahluwalia, Shankaneel Ghosh, Sakshi Roy, Joecelyn Kirani Tan, Favour Tope Adebusoye, Tomas Ferreira, Hareesha Rishab Bharadwaj, Vallabh Shet, Mrinmoy Kundu, Amanda Leong Weng Yee, Toufik Abdul-Rahman, Oday Atallah   +12 more
doaj   +1 more source

scDeepInsight: a supervised cell-type identification method for scRNA-seq data with deep learning

, 2023
Annotation of cell-types is a critical step in the analysis of single-cell RNA sequencing (scRNA-seq) data that allows the study of heterogeneity across multiple cell populations.
Lysenko, Artem, Artem Lysenko, Boroevich, Keith A, Sharma, Alok, Tatsuhiko Tsunoda, Jia, Shangru, Tsunoda, Tatsuhiko, Alok Sharma, Keith A Boroevich, Shangru Jia   +9 more
core   +1 more source