Results 71 to 80 of about 221,267 (266)

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Simplifying complex scRNA-seq data with metacells

, 2022
Single-cell RNA sequencing (scRNA-seq) provides unique opportunities for studying heterogeneous cells populations. However, in-depth single-cell transcriptomic characterization often requires profiling tens to hundreds of thousands of cells.
BILOUS, Mariia
core   +1 more source

A flexible network-based imputing-and-fusing approach towards the identification of cell types from single-cell RNA-seq data

BMC Bioinformatics, 2020
Background Single-cell RNA sequencing (scRNA-seq) provides an effective tool to investigate the transcriptomic characteristics at the single-cell resolution.
Yang Qi, Yang Guo, Huixin Jiao, Xuequn Shang   +3 more
doaj   +1 more source

scRNA-seq

10X genomics scRNA-seq expression ...
Tingyu Han (12278561)
core   +1 more source

scRNA-Seq expression profile of smp_089290 in adult male S. mansoni shows enrichment in parenchymal and neuronal cells.

, 2022
Labelled UMAP projection plot of various cell clusters highlighted by black dashed regions. smp_089290 scRNA-Seq transcript expression values shown in this plot were generated from adult male samples only. Expression values are normalised to a scale of 0–
Karl F. Hoffmann (173568), Josephine E. Forde-Thomas (6743345), Shannon E. Karinshak (9562747), Iain W. Chalmers (7871870), Dylan W. Phillips (5464316), Paul J. Brindley (7251224), Wannaporn Ittiprasert (324999), Cornelis H. Hokke (115502), Benjamin J. Hulme (7871867), Victoria H. Mann (7505045), Kathrin K. Geyer (4028333), Gilda Padalino (5244404)   +11 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Bayesian gamma-negative binomial modeling of single-cell RNA sequencing data

BMC Genomics, 2020
Background Single-cell RNA sequencing (scRNA-seq) is a powerful profiling technique at the single-cell resolution. Appropriate analysis of scRNA-seq data can characterize molecular heterogeneity and shed light into the underlying cellular process to ...
Siamak Zamani Dadaneh, Paul de Figueiredo, Sing-Hoi Sze, Mingyuan Zhou, Xiaoning Qian   +4 more
doaj   +1 more source

scRNA-Seq R scripts

, 2018
R-code used for single-cell RNA-Seq analysis of testis ...
Andreas Winterpacht (5099627), Elisabeth Bosch (1647505), Soeren Lukassen (5089880), Arif B. Ekici (146432)   +3 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source