Results 91 to 100 of about 183,994 (309)
Advanced Science, EarlyView.Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang +13 more
wiley +1 more source
European Journal of Medical Research, 2023 Single-cell ribonucleic acid sequencing (scRNA-seq) has emerged as a transformative technology in neurological and neurosurgical research, revolutionising our comprehension of complex neurological disorders.
Wireko Andrew Awuah +12 more
doaj +1 more source
Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications
Genome Biology, 2018 Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis.
Koen Van den Berge +8 more
doaj +1 more source
Bayesian gamma-negative binomial modeling of single-cell RNA sequencing data
BMC Genomics, 2020 Background Single-cell RNA sequencing (scRNA-seq) is a powerful profiling technique at the single-cell resolution. Appropriate analysis of scRNA-seq data can characterize molecular heterogeneity and shed light into the underlying cellular process to ...
Siamak Zamani Dadaneh +4 more
doaj +1 more source
, 2018 R-code used for single-cell RNA-Seq analysis of testis ...
Andreas Winterpacht (5099627) +3 more
core +1 more source
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Uncovering functional lncRNAs by scRNA-seq with ELATUS
Nature CommunicationsLong non-coding RNAs (lncRNAs) play fundamental roles in cellular processes and pathologies, regulating gene expression at multiple levels. Despite being highly cell type-specific, their study at single-cell (sc) level is challenging due to their less accurate annotation and low expression compared to protein-coding genes.
Enrique Goñi +7 more
openaire +3 more sources