Results 101 to 110 of about 221,267 (266)
PLoS Computational Biology, 2020 The emergence of single-cell RNA-seq (scRNA-seq) technology has made it possible to measure gene expression variations at cellular level. This breakthrough enables the investigation of a wider range of problems including analysis of splicing ...
Yu Hu, Kai Wang, Mingyao Li
doaj +1 more source
scRNA-seq raw data for BCL9 in cDC1
We performed single-cell sequencing (scRNA-seq) of tumors and TdLNs from B16-OVA tumor-bearing Bcl9/Bcl9l deficient mice (n = 3) and wild type mice (n = 3).
Zhongen Wu (16888458)
core +1 more source
A statistical simulator scDesign for rational scRNA-seq experimental design [PDF]
, 2018 Motivation Single-cell RNA-sequencing (scRNA-seq) has revolutionized biological sciences by revealing genome-wide gene expression levels within individual cells.
Wei Vivian Li +3 more
core +1 more source
SHARE-seq scRNA-seq matrix prior may have limited use.
, 2023 We investigated the use of the scRNA-seq matrix prior. (PDF)
Louis Gevirtzman (4714833) +3 more
core +1 more source
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Zeros in scRNA-seq data: good or bad? How to embrace or tackle zeros in scRNA-seq data analysis?
, 2020 This includes the generation of all the figures in the paper "Zeros in scRNA-seq data: good or bad? How to embrace ortackle zeros in scRNA-seq data analysis?
Ruochen, Jiang +3 more
core +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
Statistical analysis of RNA-seq and scRNA-seq expression data
, 2018 RNA-seq is a popular technique that utilizes next-generation sequencing to obtain transcriptome information from a cell population. It generates short sequences of reads from the transcriptome, which can be utilized for gene annotation, expression ...
葉信恆, Yip, Shun-hang
core +1 more source
Advanced Science, EarlyView.Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li +6 more
wiley +1 more source
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source