Results 101 to 110 of about 183,994 (309)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

A flexible network-based imputing-and-fusing approach towards the identification of cell types from single-cell RNA-seq data

BMC Bioinformatics, 2020
Background Single-cell RNA sequencing (scRNA-seq) provides an effective tool to investigate the transcriptomic characteristics at the single-cell resolution.
Yang Qi, Yang Guo, Huixin Jiao, Xuequn Shang   +3 more
doaj   +1 more source

Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq

, 2023
Abstract The corticospinal tract (CST) is clinically important for the recovery of motor functions after spinal cord injury. Despite substantial progress in understanding the biology of axon regeneration in the central nervous system (CNS), our ability to promote CST regeneration remains limited.
Hugo Kim, Junmi Saikia, Katlyn Monte, Eunmi Ha, Daniel Romaus-Sanjurjo, Joshua Sanchez, Andrea Moore, Marc Hernaiz-Llorens, Carmine Chavez-Martinez, Chimuanya Agba, Haoyue Li, Daniel Lusk, Kayla Cervantes, Binhai Zheng   +13 more
openaire   +2 more sources

scRNA-seq dataset

We collected whole lung tissues from mice at the age of 2 to 3 months for ScRNA-seq analysis. Equal number of single cells isolated from male and female WT (BioLegend, Cat#155831 or #155833) or CKO (BioLegend, Cat#155835 or#155837) or TKO (WT (BioLegend,
Zhiyu Dai (10172393)
core   +1 more source

scRNA-seq data recovery is similar across species and reproducible across replicates.

, 2022
UMAP dimensional reduction plot of scRNA-seq data with cells labeled by the stage of differentiation at which they were collected (A), along with a bar plot depicting the number of chimpanzee and human cells collected at each stage of differentiation (B),
Genevieve Housman (450745), Emilie Briscoe (12219373), Yoav Gilad (2481)   +2 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Single-cell transcriptomes reveal cell-type-specific and sample-specific gene function in human cancer

Heliyon
Accurate annotation of gene function in individual samples and even in each cell type is essential for understanding the pathogenesis of cancers. Single-cell RNA-sequencing (scRNA-seq) provides unprecedented resolution to decipher gene function. In order
Huating Yuan, Xin Liang, Xinxin Zhang, Yu Cao   +3 more
doaj   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Multimodal scRNA-seq

, 2019
Figure depicting the breadth of multimodal scRNA-seq technologies.
Moudgil, Arnav
core   +1 more source