Results 101 to 110 of about 86,859 (350)

Normalizing single-cell RNA sequencing data: challenges and opportunities [PDF]

, 2017
Single-cell transcriptomics is becoming an important component of the molecular biologist's toolkit. A critical step when analyzing data generated using this technology is normalization.
A Mortazavi, A Scialdone, A Zeisel, A-E Saliba, AA Kolodziejczyk, AA Kolodziejczyk, AA Pollen, AM Klein, Antonio Scialdone, AT Lun, B Ding, B Li, C Gawad, C Trapnell, CA Vallejos, CA Vallejos, Catalina A Vallejos, D Grün, D Risso, Davide Risso, E Pierson, E Shapiro, EZ Macosko, F Buettner, F Tang, G Finak, GK Smyth, J Lovén, JH Bullard, John C Marioni, JT Leek, L Haghverdi, L Jiang, M Goolam, M-A Dillies, MD Robinson, O Stegle, P Brennecke, PV Kharchenko, R Bacher, S Anders, S Islam, S Islam, S Katayama, SA Hardwick, SA Munro, Sandrine Dudoit, X Qiu   +47 more
core   +2 more sources

ELLIPSIS: robust quantification of splicing in scRNA-seq

Bioinformatics
Abstract Motivation Alternative splicing is a tightly regulated biological process, that due to its cell type specific behavior, calls for analysis at the single cell level. However, quantifying differential splicing in scRNA-seq is challenging due to low and uneven coverage.
Marie Van Hecke, Niko Beerenwinkel, Thibault Lootens, Jan Fostier, Robrecht Raedt, Kathleen Marchal   +5 more
openaire   +4 more sources

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Overview of scRNA-seq of Human Knee Articular Cartilage v1 [PDF]

, 2022
Merissa Olmer, Martin Lotz
openalex   +1 more source

scRNA-seq protocol v1

scRNA-seq protocol for ESC DE differentiation time course
Renhe Luo, Michael Beer, Danwei Huangfu
openaire   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Iterative point set registration for aligning scRNA-seq data [PDF]

, 2020
Amir Alavi, Ziv Bar‐Joseph
openalex   +1 more source

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

, 2020
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P., Dereka, M., Grosschedl, R., Grün, D., Herman, J., Lupar, E., Ramamoorthy, S.   +6 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Differentially expressed genes of scRNA-Seq

, 2022
Differentially expressed genes of 14 cell subpopulations of lung tissue from COPD patients in scRNA-Seq data (GSE136831) .
openaire   +1 more source