Results 111 to 120 of about 86,859 (350)

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified by scRNA-seq [PDF]

, 2021
Nicole Ulrich, Yu-chi Shen, Qianyi Ma, Kun Yang, D. Ford Hannum, Andrea Jones, Jordan H. Machlin, John F. Randolph, Yolanda R. Smith, Samantha B. Schon, Ariella Shikanov, Erica E. Marsh, Jun Z. Li, Saher Sue Hammoud   +13 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Tissue signals imprint ILC2 identity with anticipatory function. [PDF]

, 2018
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L, Erle, David J, Lee, Jinwoo, Liang, Hong-Erh, Locksley, Richard M, Molofsky, Ari B, Nussbaum, Jesse C, Ricardo-Gonzalez, Roberto R, Schneider, Christoph, Vaka, Dedeepya, Van Dyken, Steven J   +10 more
core  

Single-cell transcriptomics to explore the immune system in health and disease [PDF]

, 2018
The immune system varies in cell types, states, and locations. The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors ...
Aviv Regev, Bodenmiller, Canzar, Michael J. T. Stubbington, Orit Rozenblatt-Rosen, Reddy, Rostom, Saliba, Sarah A. Teichmann, Singer, Stoeckius, Tomczak, Wagner, Zheng   +13 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation [PDF]

, 2018
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular
A Dixit, A Jäger, A Tanay, A Wagner, AK Björklund, Antonia Wallrapp, Aviv Regev, BD Modena, Brian J. Haas, Bruce D. Levy, C Soneson, CE Prendergast, Christoph S. N. Klose, Christopher Rodman, D Cheng, Daneyal Farouq, Danielle Dionne, David Artis, DF Gudbjartsson, DR Neill, F Gerbe, GX Zheng, I Tirosh, Isaac M. Chiu, J Beale, J von Moltke, JA Hedrick, Jackson Nyman, JC Nussbaum, John J. Trombetta, JT Gaublomme, K Branchfield, K Kurakula, K Moro, K Shekhar, KJ Audrit, L Shan, LA Monticelli, LA Monticelli, M Gury-BenAri, M Moriyama, M Salimi, M Schuliga, M Singer, Matan Hofree, Michael S. Cuoco, ML Robinette, Monika S. Kowalczyk, MR Howitt, MS Kowalczyk, N Habib, NL Bray, NM Heshmat, Orit Rozenblatt-Rosen, Pankaj Baral, Patrick R. Burkett, PG Szekeres, R Satija, Raja-Elie E. Abdulnour, S Picelli, S Talbot, Samantha J. Riesenfeld, T Katsunuma, T Polte, T Sekigawa, Tanel Mahlakõiv, Timothy L. Tickle, TY Halim, Vijay K. Kuchroo, X Gu, Y Huang, YJ Chang   +71 more
core   +1 more source

constclust: Consistent clusters for scRNA-seq

, 2019
Unsupervised clustering to identify distinct cell types is a crucial early step in analyses of scRNAseq data. Current methods are dependent on a number of parameters, whose effect on the resulting solution's accuracy and reproducibility are frequently uncharacterized – resulting in ad-hoc selection by users. constclust is a novel meta-clustering method
Virshup, Isaac, Jarny Choi, Bower, Neil, Hogan, Ben, Kim-Anh Le Cao, Wells, Christine   +5 more
openaire   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine
Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex tissue microenvironments. Traditional transcriptomic approaches, such as microarrays and bulk RNA sequencing,
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
doaj   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source