Results 131 to 140 of about 86,859 (350)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Advances in the Application of Single-Cell Transcriptomics in Plant Systems and Synthetic Biology

BioDesign Research
Plants are complex systems hierarchically organized and composed of various cell types. To understand the molecular underpinnings of complex plant systems, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for revealing high ...
Md Torikul Islam, Yang Liu, Md Mahmudul Hassan, Paul E. Abraham, Jean Merlet, Alice Townsend, Daniel Jacobson, C. Robin Buell, Gerald A. Tuskan, Xiaohan Yang   +9 more
doaj   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Evaluation of pulmonary single‐cell identity specificity in scRNA‐seq analysis

Clinical and Translational Medicine, 2022
Xuanqi Liu, Guang Xu, Chengshui Chen, Yuanlin Song, Wei Wang, Xiangdong Wang   +5 more
doaj   +1 more source

Single-Cell RNA Sequencing-Based Computational Analysis to Describe Disease Heterogeneity

Frontiers in Genetics, 2019
The trillions of cells in the human body can be viewed as elementary but essential biological units that achieve different body states, but the low resolution of previous cell isolation and measurement approaches limits our understanding of the cell ...
Tao Zeng, Hao Dai
doaj   +1 more source

Referee report. For: SASCRiP: A Python workflow for preprocessing UMI count-based scRNA-seq data [version 1; peer review: 2 approved with reservations]

, 2022
Fangming Xie
openalex   +1 more source

Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson’s disease [PDF]

, 2023
Katarina Mihajlović, Gaia Ceddia, Noël Malod‐Dognin, Gabriela Novak, Dimitrios Kyriakis, Alexander Skupin, Nataša Pržulj   +6 more
openalex   +1 more source

Linked optical and gene expression profiling of single cells at high-throughput. [PDF]

, 2020
Single-cell RNA sequencing has emerged as a powerful tool for characterizing cells, but not all phenotypes of interest can be observed through changes in gene expression.
Abate, Adam R, Chang, Kai-Chun, Gartner, Zev J, Liu, Leqian, Siltanen, Christian A, Zhang, Jesse Q   +5 more
core   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Single-Cell Transcriptomics Applied in Plants

Cells
Single-cell RNA sequencing (scRNA-seq) is a high-tech method for characterizing the expression patterns of heterogeneous cells in the same tissue and has changed our evaluation of biological systems by increasing the number of individual cells analyzed ...
Yanyan Sun, Jian Sun, Chunjing Lin, Jingyong Zhang, Hao Yan, Zheyun Guan, Chunbao Zhang   +6 more
doaj   +1 more source