Results 51 to 60 of about 11,884,091 (288)

Urban Flood Depth Estimate With a New Calibrated Curve Number Runoff Prediction Model

IEEE Access, 2020
The 1954 Soil Conservation Services (SCS) runoff predictive model was adopted in engineering designs throughout the world. However, its runoff prediction reliability was under scrutiny by recent studies.
Lloyd Ling, Zulkifli Yusop, Ming Fai Chow   +2 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

A Scalable Spin‐Coating Strategy for Mesoporous Gold Thin Films toward miRNA Detection

Advanced Science, EarlyView.
A scalable spin‐coating strategy produces uniform mesoporous Au thin films with tunable thickness and high electroactive surface area on transparent substrates. The resulting architecture enables label‐free, amplification‐free detection of ovarian cancer‐associated miRNA hsa‐miR‐200c‐3p from 1 aM to 10 pM, achieving a 1.72 aM detection limit with high ...
Aditya Ashok, Emtiaz Ahmed, Arya Vasanth, Mandy Hei Man Leung, Miharu Eguchi, Md Shahriar A. Hossain, Mostafa Kamal Masud, Carlos Salomon, Yusuke Yamauchi   +8 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Comparison of the SCS-CN and Hydrograph Separation Method for Runoff Estimation in an Ungauged Basin: The Izmit Basin, Turkey [PDF]

, 2023
The separation of surface runoff and base flow is a very specific problem in water balance calculations, particularly if there is not enough measured flow data. In this study, the SCS-CN method is used to estimate the surface runoff in the ungauged Izmit
Doğan3=, Ahmet, Topçuoğlu, Meral Erdoğan, Karagüzel, Remzi, Remzi Karagüzel, Meral Erdoğan Topçuoğlu, Ahmet Doğan3=   +5 more
core   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Estimation of Peak Discharges under Different Rainfall Depth–Duration–Frequency Formulations

Hydrology, 2021
One of the main signatures of short duration storms is given by Depth–Duration–Frequency (DDF) curves. In order to provide reliable estimates for small river basins or urban catchments, generally characterized by short concentration times, in this study ...
Andrea Gioia, Beatrice Lioi, Vincenzo Totaro, Matteo Gianluca Molfetta, Ciro Apollonio, Tiziana Bisantino, Vito Iacobellis   +6 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Development of a Modified SMA Based MSCS-CN Model for Runoff Estimation

, 2015
The Soil Conservation Service Curve Number (SCS-CN) method developed by the USDA-Soil Conservation Service (SCS, 1972) is widely used for the estimation of direct runoff for a given rainfall event from small agricultural watersheds.
Jain, M. K., Berndtsson, Ronny,, Mishra, S. K., Singh, P. K., Pandey, R. P., Lund University.   +5 more
core   +2 more sources

Coordination Chemistry of Single‐Atom Catalysts in Expediating Kinetics for Advanced Lithium‐Sulfur Batteries

Advanced Science, EarlyView.
This review elucidates the catalytic mechanisms of single‐atom catalysts (SACs) in accelerating lithium polysulfides redox kinetics. Subsequently, the modifications brought by asymmetric coordination chemistry and dual‐atom coordination structures in terms of geometric configuration engineering, molecular orbital hybridization, and interfacial charge ...
Peng Chen, Jinyuan Zhao, Jing Zhang, Yidong Miao, Weihao Li, Huihua Li, Jian Wang, Yongzheng Zhang   +7 more
wiley   +1 more source