Results 61 to 70 of about 103,026 (308)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Proceedings of the 26th International Symposium on Computer Architecture (Cat. No.99CB36367), 2003 Sequential consistency (SC) is the simplest programming interface for shared-memory systems but imposes program order among all memory operations, possibly precluding high performance implementations. Release consistency (RC), however, enables the highest performance implementations but puts the burden on the programmer to specify which memory ...
Guiady, Chris +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Zoning the Flood Bearing Mordaghchai Watershed (Eastern Azerbaijan) [PDF]
نشریه جغرافیا و برنامهریزی, 2013 Flood is a natural phenomenon, which has been experienced by human being from very old times. In Iran, due to its very large area, several climates, time and local density of precipitation in most watersheds, there are many great floods in most areas of ...
Mahmoud Lajavardi +2 more
doaj
mohsennasab/SCS-Curve-Number-Generator-ArcGIS-Pro-Toolbox: Curve Number Generator v1.0
<h1>SCS Curve Number Generator</h1> <p>The SCS Curve Number Generator is an ArcGIS Python toolbox designed to facilitate hydrological analysis by generating Soil Conservation Service (SCS) Curve Numbers based on land use and soil data ...
Mohsen Tahmasebi Nasab
core +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source