Results 51 to 60 of about 85,837 (306)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2017 In one of the widely used methods to estimate surface runoff - Soil Conservation Service Curve Number (SCS-CN), the antecedent moisture condition (AMC) is categorized into three AMC levels causing irrational abrupt jumps in estimated runoff.
Mingbin Huang +7 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Zoning the Flood Bearing Mordaghchai Watershed (Eastern Azerbaijan) [PDF]
نشریه جغرافیا و برنامهریزی, 2013 Flood is a natural phenomenon, which has been experienced by human being from very old times. In Iran, due to its very large area, several climates, time and local density of precipitation in most watersheds, there are many great floods in most areas of ...
Mahmoud Lajavardi +2 more
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Patient-Reported Satisfaction with Using a Rechargeable 10 kHz Spinal Cord Stimulation Device
Journal of Pain Research, 2023 Jonathan M Hagedorn,1 Jordan Tate,2 Manish Bharara3 1iSpine Pain Physicians, Maple Grove, MN, USA; 2Southern Pain and Spine, Jasper, GA, USA; 3Clinical Affairs Department, Nevro Corp, Redwood City, CA, USACorrespondence: Jonathan M Hagedorn, iSpine Pain ...
Hagedorn JM, Tate J, Bharara M
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