Results 91 to 100 of about 6,639,635 (250)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration

Biology Open, 2016
Cystine and cysteine are important molecules for pathways such as redox signaling and regulation, and thus identifying cellular deficits upon deletion of the Saccharomyces cerevisiae cystine transporter Ers1p allows for a further understanding of cystine
Jessica A. Simpkins, Kirby E. Rickel, Marianna Madeo, Bethany A. Ahlers, Gabriel B. Carlisle, Heidi J. Nelson, Andrew L. Cardillo, Emily A. Weber, Peter F. Vitiello, David A. Pearce, Seasson P. Vitiello   +10 more
doaj   +1 more source

Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats [PDF]

, 2015
Spreading depression (SD), discovered by Leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes.
Alizadeh, L., Ghaemi, A., Lotfinia, A.A.
core  

Waveguide-QED-based measurement of a reservoir spectral density

, 2015
The spectral density (SD) function has a central role in the study of open quantum systems (OQSs). We discover a method allowing for a "static" measurement of the SD - i.e., it requires neither the OQS to be initially excited nor its time evolution ...
Ciccarello, Francesco
core   +1 more source

Publication rates on the topic of racial and ethnic diversity in dermatology versus other specialties [PDF]

, 2020
Background: The population of the U.S. is becoming more diverse every year. The field of dermatology is not following the same trend. Objective: To assess the promotion of diversity in the field of dermatology by analyzing publications focused on ...
Bray, Jeremy K, Feldman, Steven R, Huang, William W, McMichael, Amy J   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

I/D POLYMORPHISM OF ANGIOTENSINE CONVERTING ENZYME IN CHD PATIENTS OF DIFFERENT AGE AND GENDER

Российский кардиологический журнал, 2014
Aim. To analyze spread of alleles and genotypes of ACE gene in CHD patients of different gender and age and to study their realtion with MI risk.Material and methods. Totally 326 individuals of both age, Tomsk city inhabitants, aged 34-79 y. o., included
T. Yu. Rebrova, E. F. Muslimova, N. V. Panova, V. N. Serebryakova, E. E. Komarova, S. A. Afanasieva, A. A. Garganeeva, I. A. Trubacheva   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Enhancing oil palm segmentation model with GAN-based augmentation

Journal of Big Data
In digital agriculture, accurate crop detection is fundamental to developing automated systems for efficient plantation management. For oil palm, the main challenge lies in developing robust models that perform well in different environmental conditions.
Qi Bin Kwong, Yee Thung Kon, Wan Rusydiah W. Rusik, Mohd Nor Azizi Shabudin, Shahirah Shazana A. Rahman, Harikrishna Kulaveerasingam, David Ross Appleton   +6 more
doaj   +1 more source

Social cases? [PDF]

, 2006
This was a cross-sectional descriptive study of in-patients over the age of 60 years at St. Luke's hospital who were deemed to be social cases (SC). The majority (58.4%) were female and the mean age was 80 years (range 60-92, SD: 6.7 years).
Ferry, Peter, Zammit, Paul
core