Results 111 to 120 of about 3,843,987 (249)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
People by Bethlehem Cave Entrance, Bethlehem SD, Meade County
, 1966 2 x 2 b/w negative, two men and a boy in front of a wood building with stone terracingOrigin: Publicity Division SD Dept. of Highways PierreBethlehem Cave.
SD Department of Highways
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Al-Rafidain Journal of Computer Sciences and Mathematics, 2008 Ghayda A.A. Al-Talib +1 more
doaj +1 more source
Wahana Sekolah Dasar, 2019 The purpose of this study is to describe the improvement in writing description skills using the example non example model in third grade students. The results of this study indicate that the application of learning to write descriptions using non-sample
Yuswandi Diantoro +2 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Road through Spearfish Canyon, Spearfish SD, Lawrence County
4 x 5 b/w negative, curving road with pine trees in either side and rugged canyon walls to the right5274A 96-290 Black Hills Spearfish Canyon Origin Publicity Division SD Dept. of Highways PierreSpearfish Canyon 2075G-102. 1.
SD Department of Highways
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Crazy Horse Pageant, Hot Springs SD, Fall River County
2 x 2 b/w negative, eleven tipis on the plains with several people gathered in the foreground near a fireOrigin: Publicity Division SD Dept.
SD Department of Highways
core +1 more source