Results 121 to 130 of about 3,843,987 (249)
Sylvan Lake, 24572 US Highway 87, Custer SD, Custer County
4 x 5 b/w negative, seven people on a stone patio with trees and mountains in the background, two are sitting on the stone wall, four are at an outside table with a mounted umbrella, the other is sitting in a lawn chair5274A 96-290 BH General Origin ...
SD Department of Highways
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Christ on the Mount, Hermosa SD, Custer County
2 x 2 b/w negative, man striking a sculpture with a tool inside a buildingOrigin: Publicity Division SD Dept. of Highways PierreCrazy Horse. 6515D-101 Christ on the Mt.
SD Department of Highways
core +1 more source
Fishing in Spearfish Canyon, Spearfish SD, Lawrence County
, 1951 4 x 5 b/w negative, man fly-fishing next to a body of water with a waterfall in the background5274A 96-290 Black Hills Spearfish Canyon Origin Publicity Division SD Dept. of Highways PierreFishing. Spearfish Canyon 3220G-111. 22.
SD Department of Highways
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Boat on Stockade Lake, Custer SD, Custer County
4 x 5 b/w negative, four people in a small boat on a large body of water with pine trees in the foreground and backgroundOrigin: Publicity Division SD Dept.
SD Department of Highways
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source