Results 101 to 110 of about 4,922,198 (308)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Proteinograma sérico de veados-catingueiro (Mazama gouazoubira) criados em cativeiro obtido por eletroforese em gel de agarose e de poliacrilamida (SDS PAGE) Serum protein concentrations of captive brown brocket deer (Mazama gouazoubira) determined by means of agarosis and sodium dodecyl sulphate-polyacrylamide (SDS-PAGE) gel electrophoresis

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2008
The serum protein concentrations of brown brocket deer (Mazama gouazoubira) obtained by agarosis gel and sodium dodecyl sulphate-polyacrylamide (SDS-PAGE) gel were determined from blood samples of ten adult healthy animals (six females and four males ...
A.M. Santana, J.J. Fagliari, C.M.S. Camargo, A.E. Santana, J.M.B. Duarte, P.R.L. Silva   +5 more
doaj   +1 more source

SDS-PAGE analysis of sTF purification.

, 2016
SDS-PAGE 12% acrylamide gel of sTF samples stained with Coomassie Brilliant Blue R-250 showing: Lane 1: Precision Plus ProteinTM Dual Color marker (Bio-Rad, Hercules, CA, USA); Lane 2: water and sucrose combined supernatant; Lane 3: Q-Sepharose® Fast ...
John M. Boettcher (2461498), Joshua M. Gajsiewicz (3133458), Chad M. Rienstra (386757), Eric D. Watt (2359282), Kristin M. Nuzzio (1557676), James H. Morrissey (585684)   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

فراوانی ژنpxo1 در باسیلوس سرئوس، باسیلوس تورنجینزیس و باسیلوس سوبتیلیس با استفاده از تکنیک SDS-PAGE [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 1970
زمینه و هدف: در بین باسیلوس ها، باسیلوس سرئوس، باسیلوس تورنجینزیس و باسیلوس آنتراسیس دارای اهمیت زیادی می باشند که از میان آن ها باسیلوس آنتراسیس عامل بیماری سیاه زخم می باشد.
محمدجواد نمازی, غلام رضا جوادی, محمدحسن شاه حسینی, جمیله نوروزی, سیدحسین شاه چراغی, حسین صمدی, سیدهادی شاه چراغی   +6 more
doaj  

Comparative studies on seed protein characteristics in eight lines of two Gossypium species

Journal of Cotton Research, 2019
Background In order to achieve the targets aiming at the improvement of protein quality, knowledge regarding seed protein fractions and polypeptides constituting them in different crops is essential.
Arvinder SINGH, Amanjot KAUR
doaj   +1 more source

SDS-PAGE analysis of proteins with different signal peptide/adjacent amino acid combinations.

, 2016
SDS-PAGE gels illustrating purified secreted protein levels for different proteins with signal peptide/adjacent amino acid combinations. The samples were run alongside a two-colour Odyssey molecular weight marker for size determinationFull-size duplicate
Tristan J. Vaughan (2795776), Trevor C. I. Wilkinson (2795782), Sara Kidd (2795770), Gülin Güler-Gane (2795785), Sudharsan Sridharan (2795779), Natalie J. Tigue (2795773)   +5 more
core   +1 more source

SDS-PAGE and immunoblotting assay using rabbit polyclonal antisera to nsLTP, TLP and profilin.

, 2020
SDS-PAGE and immunoblotting assay using rabbit polyclonal antisera to nsLTP, TLP and profilin.
Araceli Díaz-Perales (287527), Mayte Villaba (8600376), Laura Victorio Puche (8600358), María Garrido-Arandia (8600361), Laura Martin-Pedraza (8600364), Carmen Galán (326323), Miguel Blanca (119976), José Damian López-Sánchez (8600370), Antonio Marin (8600373), Alejandro Romero Sahagún (8600367), Maria Luisa Somoza (8600379)   +10 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Identification of proteins present in culture filtrare of Mycobacterium tuberculosis DT and comparison with human tuberculin proteins by electrophoretic methods

Medical Laboratory Journal, 2012
Background and objectives: Tuberculin is the proteins existed in tuberculosis culture medium which precipitated by trichloroacetic acid (TCA) or ammonium sulfate. Tuberculin is used for diagnosis of Tuberculosis.
Sadeghi D (MSc), Mosavari N (PhD), Rafiee B (MSc), Mohamad Taheri M (MSc), Dashtipour Sh (BSc), Zare A (PhD), Ghahremanlo E (MSc), Tebyanian M (PhD)   +7 more
doaj