Results 91 to 100 of about 19,748,945 (278)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

Entre estrutura, variação e mudança: uma análise sincrônica das construções com -se indeterminador no português do Brasil [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Linguística.O foco central desta dissertação é examinar sincronicamente o processo de variação das construções de ...
Martins, Marco Antonio
core  

From Green Governance to Biodiversity Strategy: The Role of Environmentally Experienced Directors in Chinese Firms

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how directors with environmental protection (EP) backgrounds influence corporate biodiversity concern (BIO) among Chinese A‐share listed firms from 2008 to 2023. Drawing on Upper Echelons Theory, we argue that directors' environmental expertise shapes firms' biodiversity strategies.
Chengming Huang, Sultan Sikandar Mirza, Chengwei Zhang   +2 more
wiley   +1 more source

Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats

Arhiv za Higijenu Rada i Toksikologiju
Aroclor 1254 (A1254) is a mixture of polychlorinated biphenyl (PCB) congeners known to induce testicular toxicity through oxidative stress, apoptosis, and hormonal disruption.
Erkekoğlu Pınar, Balcı-Özyurt Aylin, Zeybek Naciye Dilara, Tezel-Yalçın Hülya, Yaman Ünzile, Yildiztekin Gizem, Aydın-Dilsiz Sevtap, Kızılgün Murat, İşcan Evin, Batur Tuğçe, Öztürk Mehmet, Edebal Oğuz Han, Başaran Nurşen, Koçer-Gumusel Belma   +13 more
doaj   +1 more source

Transformation of Chemical Forms and Migration Characteristics of Cadmium and Selenium During Soil Formation in Black Rock Series

Shuitu Baochi Xuebao
[Objective] Black rock series contain high amounts of cadmium (Cd) and selenium (Se). During weathering and soil formation on the rocks, the chemical form transformation and release of Cd and Se from the rocks can have an impact on the surrounding ...
REN Bailin, MA Wanzhu, ZHANG Mingkui
doaj   +1 more source

Descobrir-se – tornar-se

EXILIUM Revista de Estudos da Contemporaneidade
This text provides an initial autoethnographic reflection on the meaning of Arab identity based on the experience of being an Arab diasporic in São Paulo. Based on some personal experiences, the essay seeks to reflect on the possibilities of organizing, constructing and understanding Arab identity based on the perception of the same in São Paulo, both ...
openaire   +1 more source

Corporate ESG Greenwashing: Does Regulatory Proximity Matter?

Business Strategy and the Environment, EarlyView.
ABSTRACT Environmental, social, and governance (ESG) greenwashing undermines sustainable development, yet the influence of regulatory proximity on oversight is understudied. By introducing the “distance decay effect” from geoeconomics into ESG misconduct research and using a sample of Chinese listed firms from 2009 to 2022, this study reveals a ...
Weiqi Zhao, Zhichao Chen, Muhammad Nadeem, Guanghua Xu, Nader Atawnah   +4 more
wiley   +1 more source

Beyond the ESG Facade: Measuring and Addressing Corporate ‘Lip Service’

Business Strategy and the Environment, EarlyView.
ABSTRACT Amid growing global attention to environmental, social and governance (ESG), this study examines the misalignment between ESG disclosures and actual practices—termed ‘lip service’—using data from Chinese firms from 2006 to 2022, constructing an index to quantify it.
Jia Xu, Mingwei Liu, Helen X. H. Bao
wiley   +1 more source